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PtdInsP(2) and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium

The Ca(2+)-sensor synaptotagmin-1 that triggers neuronal exocytosis binds to negatively charged membrane lipids (mainly phosphatidylserine (PtdSer) and phosphoinositides (PtdIns)) but the molecular details of this process are not fully understood. Using quantitative thermodynamic, kinetic and struct...

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Detalles Bibliográficos
Autores principales:	Pérez-Lara, Ángel, Thapa, Anusa, Nyenhuis, Sarah B, Nyenhuis, David A, Halder, Partho, Tietzel, Michael, Tittmann, Kai, Cafiso, David S, Jahn, Reinhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123861/ https://www.ncbi.nlm.nih.gov/pubmed/27791979 http://dx.doi.org/10.7554/eLife.15886

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