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Characterization of human translesion DNA synthesis across a UV-induced DNA lesion

Translesion DNA synthesis (TLS) during S-phase uses specialized TLS DNA polymerases to replicate a DNA lesion, allowing stringent DNA synthesis to resume beyond the offending damage. Human TLS involves the conjugation of ubiquitin to PCNA clamps encircling damaged DNA and the role of this post-trans...

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Detalles Bibliográficos
Autores principales:	Hedglin, Mark, Pandey, Binod, Benkovic, Stephen J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123862/ https://www.ncbi.nlm.nih.gov/pubmed/27770570 http://dx.doi.org/10.7554/eLife.19788

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