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The association between benzodiazepine use and sleep quality in residential aged care facilities: a cross-sectional study

BACKGROUND: Benzodiazepines are commonly prescribed in residential aged care facilities (RACFs) for their sedative and anxiolytic effects. The objective of this study was to investigate the association between benzodiazepine use and sleep quality in residents of RACFs. METHODS: A cross-sectional stu...

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Autores principales: Chen, Lynna, Bell, J. Simon, Visvanathan, Renuka, Hilmer, Sarah N., Emery, Tina, Robson, Leonie, Hughes, Jessica M., Tan, Edwin C. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124287/
https://www.ncbi.nlm.nih.gov/pubmed/27888835
http://dx.doi.org/10.1186/s12877-016-0363-6
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author Chen, Lynna
Bell, J. Simon
Visvanathan, Renuka
Hilmer, Sarah N.
Emery, Tina
Robson, Leonie
Hughes, Jessica M.
Tan, Edwin C. K.
author_facet Chen, Lynna
Bell, J. Simon
Visvanathan, Renuka
Hilmer, Sarah N.
Emery, Tina
Robson, Leonie
Hughes, Jessica M.
Tan, Edwin C. K.
author_sort Chen, Lynna
collection PubMed
description BACKGROUND: Benzodiazepines are commonly prescribed in residential aged care facilities (RACFs) for their sedative and anxiolytic effects. The objective of this study was to investigate the association between benzodiazepine use and sleep quality in residents of RACFs. METHODS: A cross-sectional study involving 383 participants was conducted in six Australian RACFs. Night-time sleep quality, day-time drowsiness and day-time napping behavior were assessed using a validated questionnaire. Logistic regression was used to compute adjusted odds ratios (AORs) and 95% confidence intervals (CIs) for the association between benzodiazepine use and sleep quality. Covariates included pain, dementia severity, depression, insomnia and other sedative use. RESULTS: Of the 383 residents (mean age 87.5 years, 77.5% female), 96(25.1%) used a benzodiazepine on a regular basis. Residents who used long-acting benzodiazepines on a regular basis had higher night-time sleep quality than non-users (AOR = 4.00, 95%CI 1.06 – 15.15). Residents who used short-acting benzodiazepines on a PRN only basis had longer daytime napping times than non-users (AOR = 1.77, 95%CI 1.01 – 3.08). No benzodiazepine category was associated with day-time drowsiness. CONCLUSIONS: The association between benzodiazepine use and sleep quality is dependent on the half-life and prescribing pattern of the benzodiazepine. Short-acting PRN benzodiazepines were associated with lower night time sleep quality and longer day-time napping compared to long-acting regular benzodiazepines. Longitudinal studies are needed to determine whether these findings reflect channeling of short-acting agents to residents at higher risk of sleep disorders.
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spelling pubmed-51242872016-12-08 The association between benzodiazepine use and sleep quality in residential aged care facilities: a cross-sectional study Chen, Lynna Bell, J. Simon Visvanathan, Renuka Hilmer, Sarah N. Emery, Tina Robson, Leonie Hughes, Jessica M. Tan, Edwin C. K. BMC Geriatr Research Article BACKGROUND: Benzodiazepines are commonly prescribed in residential aged care facilities (RACFs) for their sedative and anxiolytic effects. The objective of this study was to investigate the association between benzodiazepine use and sleep quality in residents of RACFs. METHODS: A cross-sectional study involving 383 participants was conducted in six Australian RACFs. Night-time sleep quality, day-time drowsiness and day-time napping behavior were assessed using a validated questionnaire. Logistic regression was used to compute adjusted odds ratios (AORs) and 95% confidence intervals (CIs) for the association between benzodiazepine use and sleep quality. Covariates included pain, dementia severity, depression, insomnia and other sedative use. RESULTS: Of the 383 residents (mean age 87.5 years, 77.5% female), 96(25.1%) used a benzodiazepine on a regular basis. Residents who used long-acting benzodiazepines on a regular basis had higher night-time sleep quality than non-users (AOR = 4.00, 95%CI 1.06 – 15.15). Residents who used short-acting benzodiazepines on a PRN only basis had longer daytime napping times than non-users (AOR = 1.77, 95%CI 1.01 – 3.08). No benzodiazepine category was associated with day-time drowsiness. CONCLUSIONS: The association between benzodiazepine use and sleep quality is dependent on the half-life and prescribing pattern of the benzodiazepine. Short-acting PRN benzodiazepines were associated with lower night time sleep quality and longer day-time napping compared to long-acting regular benzodiazepines. Longitudinal studies are needed to determine whether these findings reflect channeling of short-acting agents to residents at higher risk of sleep disorders. BioMed Central 2016-11-26 /pmc/articles/PMC5124287/ /pubmed/27888835 http://dx.doi.org/10.1186/s12877-016-0363-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Chen, Lynna
Bell, J. Simon
Visvanathan, Renuka
Hilmer, Sarah N.
Emery, Tina
Robson, Leonie
Hughes, Jessica M.
Tan, Edwin C. K.
The association between benzodiazepine use and sleep quality in residential aged care facilities: a cross-sectional study
title The association between benzodiazepine use and sleep quality in residential aged care facilities: a cross-sectional study
title_full The association between benzodiazepine use and sleep quality in residential aged care facilities: a cross-sectional study
title_fullStr The association between benzodiazepine use and sleep quality in residential aged care facilities: a cross-sectional study
title_full_unstemmed The association between benzodiazepine use and sleep quality in residential aged care facilities: a cross-sectional study
title_short The association between benzodiazepine use and sleep quality in residential aged care facilities: a cross-sectional study
title_sort association between benzodiazepine use and sleep quality in residential aged care facilities: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124287/
https://www.ncbi.nlm.nih.gov/pubmed/27888835
http://dx.doi.org/10.1186/s12877-016-0363-6
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