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A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma
We report a case of mixed adenoneuroendocrine carcinoma (MANEC) of stomach with tubular adenoma and well-differentiated neuroendocrine tumor (WD-NET) in the primary tumor in the stomach giving rise to biphenotypic regional nodal metastases. A 35-year-old woman with abdominal pain was found to have a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124672/ https://www.ncbi.nlm.nih.gov/pubmed/27965908 http://dx.doi.org/10.1155/2016/9063634 |
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author | De Luca-Johnson, Javier Zenali, Maryam |
author_facet | De Luca-Johnson, Javier Zenali, Maryam |
author_sort | De Luca-Johnson, Javier |
collection | PubMed |
description | We report a case of mixed adenoneuroendocrine carcinoma (MANEC) of stomach with tubular adenoma and well-differentiated neuroendocrine tumor (WD-NET) in the primary tumor in the stomach giving rise to biphenotypic regional nodal metastases. A 35-year-old woman with abdominal pain was found to have a 1.8-cm gastric lesion, diagnosed as WD-NET (intermediate grade) on the biopsy. The resection specimen contained residual WD-NET; there was also a gastric adenoma adjacent to the NET and nodal metastasis with both adeno- and neuroendocrine components. The tumor was classified as MANEC. Of note, the entire gastric tissue was submitted and multiple deeper levels of the adenomatous lesion were examined; no adenocarcinoma was present in the primary lesion. While association of gastric adenoma with neuroendocrine neoplasm is rare, presence of biphenotypic metastasis originating from such a lesion is highly unusual and to the best of our knowledge has not been reported. |
format | Online Article Text |
id | pubmed-5124672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-51246722016-12-13 A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma De Luca-Johnson, Javier Zenali, Maryam Case Rep Pathol Case Report We report a case of mixed adenoneuroendocrine carcinoma (MANEC) of stomach with tubular adenoma and well-differentiated neuroendocrine tumor (WD-NET) in the primary tumor in the stomach giving rise to biphenotypic regional nodal metastases. A 35-year-old woman with abdominal pain was found to have a 1.8-cm gastric lesion, diagnosed as WD-NET (intermediate grade) on the biopsy. The resection specimen contained residual WD-NET; there was also a gastric adenoma adjacent to the NET and nodal metastasis with both adeno- and neuroendocrine components. The tumor was classified as MANEC. Of note, the entire gastric tissue was submitted and multiple deeper levels of the adenomatous lesion were examined; no adenocarcinoma was present in the primary lesion. While association of gastric adenoma with neuroendocrine neoplasm is rare, presence of biphenotypic metastasis originating from such a lesion is highly unusual and to the best of our knowledge has not been reported. Hindawi Publishing Corporation 2016 2016-11-14 /pmc/articles/PMC5124672/ /pubmed/27965908 http://dx.doi.org/10.1155/2016/9063634 Text en Copyright © 2016 J. De Luca-Johnson and M. Zenali. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report De Luca-Johnson, Javier Zenali, Maryam A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma |
title | A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma |
title_full | A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma |
title_fullStr | A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma |
title_full_unstemmed | A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma |
title_short | A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma |
title_sort | previously undescribed presentation of mixed adenoneuroendocrine carcinoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124672/ https://www.ncbi.nlm.nih.gov/pubmed/27965908 http://dx.doi.org/10.1155/2016/9063634 |
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