Cargando…

Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells

Hypertrophic differentiation occurs during in vitro chondrogenesis of mesenchymal stem cells (MSCs), decreasing the quality of the cartilage construct. Previously we identified WNT pathway antagonists Dickkopf 1 homolog (DKK1) and frizzled-related protein (FRZB) as key factors in blocking hypertroph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhong, Leilei, Huang, Xiaobin, Rodrigues, Emilie Dooms, Leijten, Jeroen C.H., Verrips, Theo, El Khattabi, Mohamed, Karperien, Marcel, Post, Janine N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2016
Materias:	Original Research Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124737/ https://www.ncbi.nlm.nih.gov/pubmed/27733096 http://dx.doi.org/10.1089/scd.2016.0222

Ejemplares similares

Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression
por: Zhong, Leilei, et al.
Publicado: (2017)

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors
por: Leijten, Jeroen CH, et al.
Publicado: (2013)

The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes
por: Zhong, Leilei, et al.
Publicado: (2015)

Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments
por: Huang, Xiaobin, et al.
Publicado: (2018)

A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy
por: Kerkhofs, Johan, et al.
Publicado: (2016)

Correlation between Gene Expression and Osteoarthritis Progression in Human
por: Zhong, Leilei, et al.
Publicado: (2016)

The Effects of the WNT-Signaling Modulators BIO and PKF118-310 on the Chondrogenic Differentiation of Human Mesenchymal Stem Cells
por: Huang, Xiaobin, et al.
Publicado: (2018)

CircCNIH4 inhibits gastric cancer progression via regulating DKK2 and FRZB expression and Wnt/β-catenin pathway
por: Shi, Qi, et al.
Publicado: (2021)

Effects of platelet rich plasma and chondrocyte co-culture on MSC chondrogenesis, hypertrophy and pathological responses
por: Ramezanifard, Rouhallah, et al.
Publicado: (2017)

Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI
por: Bakker, Brenda, et al.
Publicado: (2017)

Pleiotrophin Commits Human Bone Marrow Mesenchymal Stromal Cells towards Hypertrophy during Chondrogenesis
por: Bouderlique, Thibault, et al.
Publicado: (2014)

Suppression of Hypertrophy During in vitro Chondrogenesis of Cocultures of Human Mesenchymal Stem Cells and Nasal Chondrocytes Correlates With Lack of in vivo Calcification and Vascular Invasion
por: Anderson-Baron, Matthew, et al.
Publicado: (2021)

Importance of Timing of Platelet Lysate-Supplementation in Expanding or Redifferentiating Human Chondrocytes for Chondrogenesis
por: Rikkers, Margot, et al.
Publicado: (2020)

Functional analysis of the Frzb2 gene in Schistosoma japonicum
por: Cheng, Guifeng, et al.
Publicado: (2019)

Human Developmental Chondrogenesis as a Basis for Engineering Chondrocytes from Pluripotent Stem Cells
por: Wu, Ling, et al.
Publicado: (2013)

Direct Coculture of Human Chondrocytes and Synovium-Derived Stem Cells Enhances In Vitro Chondrogenesis
por: Kim, Tae Woo, et al.
Publicado: (2018)

Reduction of Matrix Metallopeptidase 13 and Promotion of Chondrogenesis by Zeel T in Primary Human Osteoarthritic Chondrocytes
por: Sanchez, Christelle, et al.
Publicado: (2021)

Distinct Effect of TCF4 on the NFκB Pathway in Human Primary Chondrocytes and the C20/A4 Chondrocyte Cell Line
por: Landman, E.B.M., et al.
Publicado: (2014)

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Contribute to Chondrogenesis in Coculture with Chondrocytes
por: Li, Xingfu, et al.
Publicado: (2016)

Early Determination of the Periodontal Domain by the Wnt-Antagonist Frzb/Sfrp3
por: Mitsiadis, Thimios A., et al.
Publicado: (2017)

Fetal Mesenchymal Stromal Cells Differentiating towards Chondrocytes Acquire a Gene Expression Profile Resembling Human Growth Plate Cartilage
por: van Gool, Sandy A., et al.
Publicado: (2012)

Perichondrial progenitor cells promote proliferation and chondrogenesis of mature chondrocytes
por: Ho, Chien-Liang, et al.
Publicado: (2022)

Molecular mechanisms involved in a differential association of Frzb biology with osteoarthritis and osteoporosis
por: Lories, Rik JU, et al.
Publicado: (2007)

Gene Modification of Mesenchymal Stem Cells and Articular Chondrocytes to Enhance Chondrogenesis
por: Gurusinghe, Saliya, et al.
Publicado: (2014)

Aggrecan and COMP Improve Periosteal Chondrogenesis by Delaying Chondrocyte Hypertrophic Maturation
por: Caron, Marjolein M. J., et al.
Publicado: (2020)

Three-Dimensional Scaffold-Free Fusion Culture: the Way to Enhanced Chondrogenesis of in vitro Propagated Human Articular Chondrocytes
por: Lehmann, M., et al.
Publicado: (2013)

Wnt antagonist FRZB is a muscle biomarker of denervation atrophy in amyotrophic lateral sclerosis
por: Kwan, Thaddaeus, et al.
Publicado: (2020)

FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrity
por: Oh, Chang-Kyu, et al.
Publicado: (2021)

Cell-Mediated Degradation Regulates Human Mesenchymal Stem Cell Chondrogenesis and Hypertrophy in MMP-Sensitive Hyaluronic Acid Hydrogels
por: Feng, Qian, et al.
Publicado: (2014)

Effect of alginate concentration on chondrogenesis of co-cultured human adipose-derived stem cells and nasal chondrocytes: a biological study
por: Ewa-Choy, Y. W., et al.
Publicado: (2017)

Human fetal cartilage-derived chondrocytes and chondroprogenitors display a greater commitment to chondrogenesis than adult cartilage resident cells
por: Vinod, Elizabeth, et al.
Publicado: (2023)

FRZB affects Staphylococcus aureus‑induced osteomyelitis in human bone marrow derived stem cells by regulating the Wnt/β‑catenin signaling pathway
por: Li, Xin, et al.
Publicado: (2023)

Induction and prevention of chondrocyte hypertrophy in culture
Publicado: (1989)

The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation
por: Chau, Michael, et al.
Publicado: (2022)

Methylation Patterns of DKK1, DKK3 and GSK3β Are Accompanied with Different Expression Levels in Human Astrocytoma
por: Kafka, Anja, et al.
Publicado: (2021)

Suppressing Chondrocyte Hypertrophy to Build Better Cartilage
por: Shigley, Christian, et al.
Publicado: (2023)

Distinct roles of DKK1 and DKK2 in tumor angiogenesis
por: Park, Hongryeol, et al.
Publicado: (2013)

Enhanced chondrogenesis from human embryonic stem cells
por: Wang, Tao, et al.
Publicado: (2019)

Effect of Inflammatory Signaling on Human Articular Chondrocyte Hypertrophy: Potential Involvement of Tissue Repair Macrophages
por: Ferrao Blanco, Mauricio N., et al.
Publicado: (2021)

Biological and Chemical Removal of Primary Cilia Affects Mechanical Activation of Chondrogenesis Markers in Chondroprogenitors and Hypertrophic Chondrocytes
por: Deren, Matthew E., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_vep5qm7omdmaj0443gmbsamchi