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Down-regulation of coasy, the gene associated with NBIA-VI, reduces Bmp signaling, perturbs dorso-ventral patterning and alters neuronal development in zebrafish

Mutations in Pantothenate kinase 2 and Coenzyme A (CoA) synthase (COASY), genes involved in CoA biosynthesis, are associated with rare neurodegenerative disorders with brain iron accumulation. We showed that zebrafish pank2 gene plays an essential role in brain and vasculature development. Now we ex...

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Detalles Bibliográficos
Autores principales:	Khatri, Deepak, Zizioli, Daniela, Tiso, Natascia, Facchinello, Nicola, Vezzoli, Sara, Gianoncelli, Alessandra, Memo, Maurizio, Monti, Eugenio, Borsani, Giuseppe, Finazzi, Dario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124858/ https://www.ncbi.nlm.nih.gov/pubmed/27892483 http://dx.doi.org/10.1038/srep37660

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