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Environmental factors linked to depression vulnerability are associated with altered cerebellar resting-state synchronization
Hosting nearly eighty percent of all human neurons, the cerebellum is functionally connected to large regions of the brain. Accumulating data suggest that some cerebellar resting-state alterations may constitute a key candidate mechanism for depressive psychopathology. While there is some evidence l...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124945/ https://www.ncbi.nlm.nih.gov/pubmed/27892484 http://dx.doi.org/10.1038/srep37384 |
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author | Córdova-Palomera, Aldo Tornador, Cristian Falcón, Carles Bargalló, Nuria Brambilla, Paolo Crespo-Facorro, Benedicto Deco, Gustavo Fañanás, Lourdes |
author_facet | Córdova-Palomera, Aldo Tornador, Cristian Falcón, Carles Bargalló, Nuria Brambilla, Paolo Crespo-Facorro, Benedicto Deco, Gustavo Fañanás, Lourdes |
author_sort | Córdova-Palomera, Aldo |
collection | PubMed |
description | Hosting nearly eighty percent of all human neurons, the cerebellum is functionally connected to large regions of the brain. Accumulating data suggest that some cerebellar resting-state alterations may constitute a key candidate mechanism for depressive psychopathology. While there is some evidence linking cerebellar function and depression, two topics remain largely unexplored. First, the genetic or environmental roots of this putative association have not been elicited. Secondly, while different mathematical representations of resting-state fMRI patterns can embed diverse information of relevance for health and disease, many of them have not been studied in detail regarding the cerebellum and depression. Here, high-resolution fMRI scans were examined to estimate functional connectivity patterns across twenty-six cerebellar regions in a sample of 48 identical twins (24 pairs) informative for depression liability. A network-based statistic approach was employed to analyze cerebellar functional networks built using three methods: the conventional approach of filtered BOLD fMRI time-series, and two analytic components of this oscillatory activity (amplitude envelope and instantaneous phase). The findings indicate that some environmental factors may lead to depression vulnerability through alterations of the neural oscillatory activity of the cerebellum during resting-state. These effects may be observed particularly when exploring the amplitude envelope of fMRI oscillations. |
format | Online Article Text |
id | pubmed-5124945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51249452016-12-08 Environmental factors linked to depression vulnerability are associated with altered cerebellar resting-state synchronization Córdova-Palomera, Aldo Tornador, Cristian Falcón, Carles Bargalló, Nuria Brambilla, Paolo Crespo-Facorro, Benedicto Deco, Gustavo Fañanás, Lourdes Sci Rep Article Hosting nearly eighty percent of all human neurons, the cerebellum is functionally connected to large regions of the brain. Accumulating data suggest that some cerebellar resting-state alterations may constitute a key candidate mechanism for depressive psychopathology. While there is some evidence linking cerebellar function and depression, two topics remain largely unexplored. First, the genetic or environmental roots of this putative association have not been elicited. Secondly, while different mathematical representations of resting-state fMRI patterns can embed diverse information of relevance for health and disease, many of them have not been studied in detail regarding the cerebellum and depression. Here, high-resolution fMRI scans were examined to estimate functional connectivity patterns across twenty-six cerebellar regions in a sample of 48 identical twins (24 pairs) informative for depression liability. A network-based statistic approach was employed to analyze cerebellar functional networks built using three methods: the conventional approach of filtered BOLD fMRI time-series, and two analytic components of this oscillatory activity (amplitude envelope and instantaneous phase). The findings indicate that some environmental factors may lead to depression vulnerability through alterations of the neural oscillatory activity of the cerebellum during resting-state. These effects may be observed particularly when exploring the amplitude envelope of fMRI oscillations. Nature Publishing Group 2016-11-28 /pmc/articles/PMC5124945/ /pubmed/27892484 http://dx.doi.org/10.1038/srep37384 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Córdova-Palomera, Aldo Tornador, Cristian Falcón, Carles Bargalló, Nuria Brambilla, Paolo Crespo-Facorro, Benedicto Deco, Gustavo Fañanás, Lourdes Environmental factors linked to depression vulnerability are associated with altered cerebellar resting-state synchronization |
title | Environmental factors linked to depression vulnerability are associated with altered cerebellar resting-state synchronization |
title_full | Environmental factors linked to depression vulnerability are associated with altered cerebellar resting-state synchronization |
title_fullStr | Environmental factors linked to depression vulnerability are associated with altered cerebellar resting-state synchronization |
title_full_unstemmed | Environmental factors linked to depression vulnerability are associated with altered cerebellar resting-state synchronization |
title_short | Environmental factors linked to depression vulnerability are associated with altered cerebellar resting-state synchronization |
title_sort | environmental factors linked to depression vulnerability are associated with altered cerebellar resting-state synchronization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124945/ https://www.ncbi.nlm.nih.gov/pubmed/27892484 http://dx.doi.org/10.1038/srep37384 |
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