Genetics and pathogenesis of idiopathic scoliosis

Idiopathic scoliosis (IS), the most common spinal deformity, affects otherwise healthy children and adolescents during growth. The aetiology is still unknown, although genetic factors are believed to be important. The present review corroborates the understanding of IS as a complex disease with a po...

Descripción completa

Detalles Bibliográficos
Autores principales: Grauers, A., Einarsdottir, E., Gerdhem, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125035/
https://www.ncbi.nlm.nih.gov/pubmed/27933320
http://dx.doi.org/10.1186/s13013-016-0105-8
_version_ 1782469920861192192
author Grauers, A.
Einarsdottir, E.
Gerdhem, P.
author_facet Grauers, A.
Einarsdottir, E.
Gerdhem, P.
author_sort Grauers, A.
collection PubMed
description Idiopathic scoliosis (IS), the most common spinal deformity, affects otherwise healthy children and adolescents during growth. The aetiology is still unknown, although genetic factors are believed to be important. The present review corroborates the understanding of IS as a complex disease with a polygenic background. Presumably IS can be due to a spectrum of genetic risk variants, ranging from very rare or even private to very common. The most promising candidate genes are highlighted.
format Online
Article
Text
id pubmed-5125035
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-51250352016-12-08 Genetics and pathogenesis of idiopathic scoliosis Grauers, A. Einarsdottir, E. Gerdhem, P. Scoliosis Spinal Disord Review Idiopathic scoliosis (IS), the most common spinal deformity, affects otherwise healthy children and adolescents during growth. The aetiology is still unknown, although genetic factors are believed to be important. The present review corroborates the understanding of IS as a complex disease with a polygenic background. Presumably IS can be due to a spectrum of genetic risk variants, ranging from very rare or even private to very common. The most promising candidate genes are highlighted. BioMed Central 2016-11-28 /pmc/articles/PMC5125035/ /pubmed/27933320 http://dx.doi.org/10.1186/s13013-016-0105-8 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Grauers, A.
Einarsdottir, E.
Gerdhem, P.
Genetics and pathogenesis of idiopathic scoliosis
title Genetics and pathogenesis of idiopathic scoliosis
title_full Genetics and pathogenesis of idiopathic scoliosis
title_fullStr Genetics and pathogenesis of idiopathic scoliosis
title_full_unstemmed Genetics and pathogenesis of idiopathic scoliosis
title_short Genetics and pathogenesis of idiopathic scoliosis
title_sort genetics and pathogenesis of idiopathic scoliosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125035/
https://www.ncbi.nlm.nih.gov/pubmed/27933320
http://dx.doi.org/10.1186/s13013-016-0105-8
work_keys_str_mv AT grauersa geneticsandpathogenesisofidiopathicscoliosis
AT einarsdottire geneticsandpathogenesisofidiopathicscoliosis
AT gerdhemp geneticsandpathogenesisofidiopathicscoliosis

Ejemplares similares