RNF4-Dependent Oncogene Activation by Protein Stabilization

Ubiquitylation regulates signaling pathways critical for cancer development and, in many cases, targets proteins for degradation. Here, we report that ubiquitylation by RNF4 stabilizes otherwise short-lived oncogenic transcription factors, including β-catenin, Myc, c-Jun, and the Notch intracellular...

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Detalles Bibliográficos
Autores principales: Thomas, Jane J., Abed, Mona, Heuberger, Julian, Novak, Rostislav, Zohar, Yaniv, Beltran Lopez, Angela P., Trausch-Azar, Julie S., Ilagan, Ma. Xenia G., Benhamou, David, Dittmar, Gunnar, Kopan, Raphael, Birchmeier, Walter, Schwartz, Alan L., Orian, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125238/
https://www.ncbi.nlm.nih.gov/pubmed/27653698
http://dx.doi.org/10.1016/j.celrep.2016.08.024

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