Delayed High-dose Methotrexate Excretion and Influencing Factors in Osteosarcoma Patients

BACKGROUND: High-dose methotrexate (HD-MTX) with folinic acid (leucovorin) rescue is “gold standard” therapy for osteosarcoma. Plasma concentrations of methotrexate (MTX) are closely related to its efficacy and toxicity. Delayed excretion of MTX can lead to serious adverse reactions that may result...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Zhang, Qing, Zheng, Ting-Ting, Zhen, Jian-Cun, Niu, Xiao-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125329/
https://www.ncbi.nlm.nih.gov/pubmed/27779157
http://dx.doi.org/10.4103/0366-6999.192781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125329/
https://www.ncbi.nlm.nih.gov/pubmed/27779157
http://dx.doi.org/10.4103/0366-6999.192781

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