Multivalent Interactions of Human Primary Amine Oxidase with the V and C2(2) Domains of Sialic Acid-Binding Immunoglobulin-Like Lectin-9 Regulate Its Binding and Amine Oxidase Activity

Sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) on leukocyte surface is a counter-receptor for endothelial cell surface adhesin, human primary amine oxidase (hAOC3), a target protein for anti-inflammatory agents. This interaction can be used to detect inflammation and cancer in vivo, sin...

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Detalles Bibliográficos
Autores principales: Elovaara, Heli, Parkash, Vimal, Fair-Mäkelä, Ruth, Salo-Ahen, Outi M. H., Guédez, Gabriela, Bligt-Lindén, Eva, Grönholm, Janne, Jalkanen, Sirpa, Salminen, Tiina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125647/
https://www.ncbi.nlm.nih.gov/pubmed/27893774
http://dx.doi.org/10.1371/journal.pone.0166935

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