The Open Form Inducer Approach for Structure-Based Drug Design

Many open form (OF) structures of drug targets were obtained a posteriori by analysis of co-crystals with inhibitors. Therefore, obtaining the OF structure of a drug target a priori will accelerate development of potent inhibitors. In addition to its small active site, Trypanosoma cruzi dihydroorota...

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Detalles Bibliográficos
Autores principales: Inaoka, Daniel Ken, Iida, Maiko, Tabuchi, Toshiyuki, Honma, Teruki, Lee, Nayoung, Hashimoto, Satoshi, Matsuoka, Shigeru, Kuranaga, Takefumi, Sato, Kazuhito, Shiba, Tomoo, Sakamoto, Kimitoshi, Balogun, Emmanuel Oluwadare, Suzuki, Shigeo, Nara, Takeshi, da Rocha, Josmar Rodrigues, Montanari, Carlos Alberto, Tanaka, Akiko, Inoue, Masayuki, Kita, Kiyoshi, Harada, Shigeharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125662/
https://www.ncbi.nlm.nih.gov/pubmed/27893848
http://dx.doi.org/10.1371/journal.pone.0167078

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