TGFbeta Induces Binucleation/Polyploidization in Hepatocytes through a Src-Dependent Cytokinesis Failure

In all mammals, the adult liver shows binucleated as well as mononucleated polyploid hepatocytes. The hepatic polyploidization starts after birth with an extensive hepatocyte binucleation and generates hepatocytes of several ploidy classes. While the functional significance of hepatocyte polyploidy...

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Detalles Bibliográficos
Autores principales: De Santis Puzzonia, Marco, Cozzolino, Angela Maria, Grassi, Germana, Bisceglia, Francesca, Strippoli, Raffaele, Guarguaglini, Giulia, Citarella, Franca, Sacchetti, Benedetto, Tripodi, Marco, Marchetti, Alessandra, Amicone, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125678/
https://www.ncbi.nlm.nih.gov/pubmed/27893804
http://dx.doi.org/10.1371/journal.pone.0167158

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