Astrocyte Structural and Molecular Response to Elevated Intraocular Pressure Occurs Rapidly and Precedes Axonal Tubulin Rearrangement within the Optic Nerve Head in a Rat Model

Glaucomatous axon injury occurs at the level of the optic nerve head (ONH) in response to uncontrolled intraocular pressure (IOP). The temporal response of ONH astrocytes (glial cells responsible for axonal support) to elevated IOP remains unknown. Here, we evaluate the response of actin-based astro...

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Detalles Bibliográficos
Autores principales: Tehrani, Shandiz, Davis, Lauren, Cepurna, William O., Choe, Tiffany E., Lozano, Diana C., Monfared, Ashley, Cooper, Lauren, Cheng, Joshua, Johnson, Elaine C., Morrison, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125687/
https://www.ncbi.nlm.nih.gov/pubmed/27893827
http://dx.doi.org/10.1371/journal.pone.0167364

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