Blocking Synthesis of the Variant Surface Glycoprotein Coat in Trypanosoma brucei Leads to an Increase in Macrophage Phagocytosis Due to Reduced Clearance of Surface Coat Antibodies

The extracellular bloodstream form parasite Trypanosoma brucei is supremely adapted to escape the host innate and adaptive immune system. Evasion is mediated through an antigenically variable Variant Surface Glycoprotein (VSG) coat, which is recycled at extraordinarily high rates. Blocking VSG synth...

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Detalles Bibliográficos
Autores principales: Cheung, Jackie L. Y., Wand, Nadina V., Ooi, Cher-Pheng, Ridewood, Sophie, Wheeler, Richard J., Rudenko, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125712/
https://www.ncbi.nlm.nih.gov/pubmed/27893860
http://dx.doi.org/10.1371/journal.ppat.1006023

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