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The interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: A new approach to risk assessment and disease prevention

We have previously shown that there is a complex and dynamic biological interaction between acute mental stress and acute release of inflammatory factors into the blood stream in relation to heart disease. We now hypothesize that the presence of chronic psychosocial stress may modify the weight of s...

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Autores principales: Lazzarino, Antonio Ivan, Hamer, Mark, Gaze, David, Collinson, Paul, Rumley, Ann, Lowe, Gordon, Steptoe, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126095/
https://www.ncbi.nlm.nih.gov/pubmed/27663429
http://dx.doi.org/10.1016/j.ypmed.2016.09.018
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author Lazzarino, Antonio Ivan
Hamer, Mark
Gaze, David
Collinson, Paul
Rumley, Ann
Lowe, Gordon
Steptoe, Andrew
author_facet Lazzarino, Antonio Ivan
Hamer, Mark
Gaze, David
Collinson, Paul
Rumley, Ann
Lowe, Gordon
Steptoe, Andrew
author_sort Lazzarino, Antonio Ivan
collection PubMed
description We have previously shown that there is a complex and dynamic biological interaction between acute mental stress and acute release of inflammatory factors into the blood stream in relation to heart disease. We now hypothesize that the presence of chronic psychosocial stress may modify the weight of single test results for inflammation as a predictor of heart disease. Using a cross-sectional design, 500 participants free from heart disease drawn from the Whitehall II study in UK in 2006–2008 were tested for plasma fibrinogen as an inflammatory factor, financial strain as a marker of chronic psychosocial stress, coronary calcification measured using computed tomography, and for plasma high-sensitivity cardiac troponin T (HS-CTnT) as a marker of cardiac risk. Fibrinogen concentration levels above the average were associated with a 5-fold increase in the odds of HS-CTnT positivity only among individuals with financial strain (N = 208, OR = 4.73, 95%CI = 1.67 to 13.40, P = 0.003). Fibrinogen was in fact not associated with HS-CTnT positivity in people without financial strain despite the larger size of that subsample (n = 292, OR = 0.84, 95%CI = 0.42 to 1.67, P = 0.622). A test for interaction on the full sample (N = 500) showed a P value of 0.010 after adjusting for a range of demographics, health behaviours, traditional cardiovascular risk factors, psychosocial stressors, inflammatory cytokines, and coronary calcification. In conclusion, elevated fibrinogen seems to be cardio-toxic only when is combined with financial strain. Chronic psychosocial stress may modify the meaning that we should give to single test results for inflammation. Further research is needed to confirm our results.
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spelling pubmed-51260952016-12-05 The interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: A new approach to risk assessment and disease prevention Lazzarino, Antonio Ivan Hamer, Mark Gaze, David Collinson, Paul Rumley, Ann Lowe, Gordon Steptoe, Andrew Prev Med Article We have previously shown that there is a complex and dynamic biological interaction between acute mental stress and acute release of inflammatory factors into the blood stream in relation to heart disease. We now hypothesize that the presence of chronic psychosocial stress may modify the weight of single test results for inflammation as a predictor of heart disease. Using a cross-sectional design, 500 participants free from heart disease drawn from the Whitehall II study in UK in 2006–2008 were tested for plasma fibrinogen as an inflammatory factor, financial strain as a marker of chronic psychosocial stress, coronary calcification measured using computed tomography, and for plasma high-sensitivity cardiac troponin T (HS-CTnT) as a marker of cardiac risk. Fibrinogen concentration levels above the average were associated with a 5-fold increase in the odds of HS-CTnT positivity only among individuals with financial strain (N = 208, OR = 4.73, 95%CI = 1.67 to 13.40, P = 0.003). Fibrinogen was in fact not associated with HS-CTnT positivity in people without financial strain despite the larger size of that subsample (n = 292, OR = 0.84, 95%CI = 0.42 to 1.67, P = 0.622). A test for interaction on the full sample (N = 500) showed a P value of 0.010 after adjusting for a range of demographics, health behaviours, traditional cardiovascular risk factors, psychosocial stressors, inflammatory cytokines, and coronary calcification. In conclusion, elevated fibrinogen seems to be cardio-toxic only when is combined with financial strain. Chronic psychosocial stress may modify the meaning that we should give to single test results for inflammation. Further research is needed to confirm our results. Academic Press 2016-12 /pmc/articles/PMC5126095/ /pubmed/27663429 http://dx.doi.org/10.1016/j.ypmed.2016.09.018 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lazzarino, Antonio Ivan
Hamer, Mark
Gaze, David
Collinson, Paul
Rumley, Ann
Lowe, Gordon
Steptoe, Andrew
The interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: A new approach to risk assessment and disease prevention
title The interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: A new approach to risk assessment and disease prevention
title_full The interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: A new approach to risk assessment and disease prevention
title_fullStr The interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: A new approach to risk assessment and disease prevention
title_full_unstemmed The interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: A new approach to risk assessment and disease prevention
title_short The interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: A new approach to risk assessment and disease prevention
title_sort interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: a new approach to risk assessment and disease prevention
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126095/
https://www.ncbi.nlm.nih.gov/pubmed/27663429
http://dx.doi.org/10.1016/j.ypmed.2016.09.018
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