Activation of WNT/β-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61

Pancreatic ductal adenocarcinoma (PDAC), a poor prognostic cancer, commonly develops following activating mutations in the KRAS oncogene. Activation of WNT signaling is also commonly observed in PDAC. To ascertain the impact of postnatal activation of WNT-stimulated signaling pathways in PDAC develo...

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Detalles Bibliográficos
Autores principales: Sano, Makoto, Driscoll, David R., DeJesus-Monge, Wilfredo E., Quattrochi, Brian, Appleman, Victoria A., Ou, Jianhong, Zhu, Lihua Julie, Yoshida, Nao, Yamazaki, Shintaro, Takayama, Tadatoshi, Sugitani, Masahiko, Nemoto, Norimichi, Klimstra, David S., Lewis, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2016
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126137/
https://www.ncbi.nlm.nih.gov/pubmed/27889647
http://dx.doi.org/10.1016/j.neo.2016.11.004

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