α1-Blockers in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction: Is Silodosin Different?

Available α1-blockers (ABs) have different profiles of receptor selectivity. Silodosin exhibits the highest selectivity for the α(1A) adrenergic receptor. This pharmacological feature couples with a singular urodynamic and clinical profile. The magnitude of bladder outlet obstruction improvement in...

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Detalles Bibliográficos
Autores principales: Roehrborn, Claus G., Cruz, Francisco, Fusco, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126182/
https://www.ncbi.nlm.nih.gov/pubmed/27752927
http://dx.doi.org/10.1007/s12325-016-0423-5
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author Roehrborn, Claus G.
Cruz, Francisco
Fusco, Ferdinando
author_facet Roehrborn, Claus G.
Cruz, Francisco
Fusco, Ferdinando
author_sort Roehrborn, Claus G.
collection PubMed
description Available α1-blockers (ABs) have different profiles of receptor selectivity. Silodosin exhibits the highest selectivity for the α(1A) adrenergic receptor. This pharmacological feature couples with a singular urodynamic and clinical profile. The magnitude of bladder outlet obstruction improvement in patients receiving silodosin is higher if compared to other ABs. From a clinical point of view, current evidence suggests an advantage in favor of silodosin in terms of nocturia improvement and cardiovascular safety. The incidence of ejaculatory dysfunction with silodosin is higher compared to other Abs.
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spelling pubmed-51261822016-12-13 α1-Blockers in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction: Is Silodosin Different? Roehrborn, Claus G. Cruz, Francisco Fusco, Ferdinando Adv Ther Review Available α1-blockers (ABs) have different profiles of receptor selectivity. Silodosin exhibits the highest selectivity for the α(1A) adrenergic receptor. This pharmacological feature couples with a singular urodynamic and clinical profile. The magnitude of bladder outlet obstruction improvement in patients receiving silodosin is higher if compared to other ABs. From a clinical point of view, current evidence suggests an advantage in favor of silodosin in terms of nocturia improvement and cardiovascular safety. The incidence of ejaculatory dysfunction with silodosin is higher compared to other Abs. Springer Healthcare 2016-10-17 2016 /pmc/articles/PMC5126182/ /pubmed/27752927 http://dx.doi.org/10.1007/s12325-016-0423-5 Text en © The Author(s) 2016 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Roehrborn, Claus G.
Cruz, Francisco
Fusco, Ferdinando
α1-Blockers in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction: Is Silodosin Different?
title α1-Blockers in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction: Is Silodosin Different?
title_full α1-Blockers in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction: Is Silodosin Different?
title_fullStr α1-Blockers in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction: Is Silodosin Different?
title_full_unstemmed α1-Blockers in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction: Is Silodosin Different?
title_short α1-Blockers in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction: Is Silodosin Different?
title_sort α1-blockers in men with lower urinary tract symptoms suggestive of benign prostatic obstruction: is silodosin different?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126182/
https://www.ncbi.nlm.nih.gov/pubmed/27752927
http://dx.doi.org/10.1007/s12325-016-0423-5
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