A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation

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Acetyl-CoA carboxylases (ACCs) are crucial metabolic enzymes and attractive targets for drug discovery. Eukaryotic acetyl-CoA carboxylases are 250 kDa single-chain, multi-domain enzymes and function as dimers and higher oligomers. Their catalytic activity is tightly regulated by phosphorylation and...

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Detalles Bibliográficos
Autores principales: Wei, Jia, Zhang, Yixiao, Yu, Tai-Yuan, Sadre-Bazzaz, Kianoush, Rudolph, Michael J, Amodeo, Gabriele A, Symington, Lorraine S, Walz, Thomas, Tong, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126230/
https://www.ncbi.nlm.nih.gov/pubmed/27990296
http://dx.doi.org/10.1038/celldisc.2016.44
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