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HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual

The HIV envelope glycoprotein (Env) is extensively modified with host-derived N-linked glycans. The high density of glycosylation on the viral spike limits enzymatic processing, resulting in numerous underprocessed oligomannose-type glycans. This extensive glycosylation not only shields conserved re...

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Detalles Bibliográficos
Autores principales:	Coss, Karen P., Vasiljevic, Snezana, Pritchard, Laura K., Krumm, Stefanie A., Glaze, Molly, Madzorera, Sharon, Moore, Penny L., Crispin, Max, Doores, Katie J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126371/ https://www.ncbi.nlm.nih.gov/pubmed/27707925 http://dx.doi.org/10.1128/JVI.01542-16

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