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Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy

Purpose. The objective is to compare lateralizing ability of three quantitative MR (qMRI) modalities to depict changes of hippocampal architecture with clinical entities in temporal lobe epilepsy. Methods. We evaluated 14 patients with clinical and EEG proven diagnosis of unilateral TLE and 15 healt...

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Autores principales: Ercan, Karabekir, Gunbey, Hediye Pinar, Bilir, Erhan, Zan, Elcin, Arslan, Halil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126436/
https://www.ncbi.nlm.nih.gov/pubmed/27974864
http://dx.doi.org/10.1155/2016/5923243
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author Ercan, Karabekir
Gunbey, Hediye Pinar
Bilir, Erhan
Zan, Elcin
Arslan, Halil
author_facet Ercan, Karabekir
Gunbey, Hediye Pinar
Bilir, Erhan
Zan, Elcin
Arslan, Halil
author_sort Ercan, Karabekir
collection PubMed
description Purpose. The objective is to compare lateralizing ability of three quantitative MR (qMRI) modalities to depict changes of hippocampal architecture with clinical entities in temporal lobe epilepsy. Methods. We evaluated 14 patients with clinical and EEG proven diagnosis of unilateral TLE and 15 healthy volunteers. T1-weighted 3D dataset for volumetry, single-voxel (1)H MR spectroscopy (MRS), and diffusion tensor imaging (DTI) were performed for bilateral hippocampi of all subjects. Results. Individual volumetric measurements provided accurate lateralization in 85% of the patients, spectroscopy in 57%, and DTI in 57%. Higher lateralization ratios were acquired combining volumetry-spectroscopy (85%), spectroscopy-DTI (85%), and volumetry-DTI (100%). Significantly decreased NAA/(Cho+Cr) ratios (p = 0.002) and increased FA (p = 0.001) values were obtained in ipsilateral to epileptogenic hippocampus. Duration of epilepsy and FA values showed a significant negative correlation (p = 0.016, r = −0.847). The history of febrile convulsion associated with ipsilateral increased ADC values (p = 0.015, r = 0.851) and reduced NAA/(Cho+Cr) ratios (p = 0.047, r = −761). Conclusion. Volumetry, MRS, and DTI studies provide complementary information of hippocampal pathology. For lateralization of epileptogenic focus and preoperative examination, volumetry-DTI combination may be indicative of diagnostic accuracy.
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spelling pubmed-51264362016-12-14 Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy Ercan, Karabekir Gunbey, Hediye Pinar Bilir, Erhan Zan, Elcin Arslan, Halil Dis Markers Research Article Purpose. The objective is to compare lateralizing ability of three quantitative MR (qMRI) modalities to depict changes of hippocampal architecture with clinical entities in temporal lobe epilepsy. Methods. We evaluated 14 patients with clinical and EEG proven diagnosis of unilateral TLE and 15 healthy volunteers. T1-weighted 3D dataset for volumetry, single-voxel (1)H MR spectroscopy (MRS), and diffusion tensor imaging (DTI) were performed for bilateral hippocampi of all subjects. Results. Individual volumetric measurements provided accurate lateralization in 85% of the patients, spectroscopy in 57%, and DTI in 57%. Higher lateralization ratios were acquired combining volumetry-spectroscopy (85%), spectroscopy-DTI (85%), and volumetry-DTI (100%). Significantly decreased NAA/(Cho+Cr) ratios (p = 0.002) and increased FA (p = 0.001) values were obtained in ipsilateral to epileptogenic hippocampus. Duration of epilepsy and FA values showed a significant negative correlation (p = 0.016, r = −0.847). The history of febrile convulsion associated with ipsilateral increased ADC values (p = 0.015, r = 0.851) and reduced NAA/(Cho+Cr) ratios (p = 0.047, r = −761). Conclusion. Volumetry, MRS, and DTI studies provide complementary information of hippocampal pathology. For lateralization of epileptogenic focus and preoperative examination, volumetry-DTI combination may be indicative of diagnostic accuracy. Hindawi Publishing Corporation 2016 2016-11-15 /pmc/articles/PMC5126436/ /pubmed/27974864 http://dx.doi.org/10.1155/2016/5923243 Text en Copyright © 2016 Karabekir Ercan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ercan, Karabekir
Gunbey, Hediye Pinar
Bilir, Erhan
Zan, Elcin
Arslan, Halil
Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy
title Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy
title_full Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy
title_fullStr Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy
title_full_unstemmed Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy
title_short Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy
title_sort comparative lateralizing ability of multimodality mri in temporal lobe epilepsy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126436/
https://www.ncbi.nlm.nih.gov/pubmed/27974864
http://dx.doi.org/10.1155/2016/5923243
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