Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis

We report a case of glomerulopathy in a 36-year-old Japanese woman with primary Sjögren syndrome (pSS). The first renal biopsy suggested membranous glomerulonephritis. However, repeat biopsy was performed after 16 years because of increased proteinuria, revealing membranoproliferative glomerulonephr...

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Detalles Bibliográficos
Autores principales: Yabuuchi, Junko, Suwabe, Tatsuya, Ueno, Toshiharu, Hoshino, Junichi, Sekine, Akinari, Hayami, Noriko, Oguro, Masahiko, Kunisawa, Kyohei, Kawada, Masahiro, Yamanouchi, Masayuki, Sumida, Keiichi, Mizuno, Hiroki, Hasegawa, Eiko, Sawa, Naoki, Takaichi, Kenmei, Ohashi, Kenichi, Fujii, Takeshi, Ubara, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126589/
https://www.ncbi.nlm.nih.gov/pubmed/27904866
http://dx.doi.org/10.1159/000452298
Descripción
Sumario:We report a case of glomerulopathy in a 36-year-old Japanese woman with primary Sjögren syndrome (pSS). The first renal biopsy suggested membranous glomerulonephritis. However, repeat biopsy was performed after 16 years because of increased proteinuria, revealing membranoproliferative glomerulonephritis with mesangial deposits, subendothelial deposits, and subepithelial deposits. Immunofluorescent studies showed predominant deposition of IgG2 and IgG4. This patient was positive for antinuclear antibody and anti-SS-A antibody. Sicca syndrome was confirmed by a positive Schirmer test and positive Rose Bengal test. Therefore, pSS-related glomerulopathy was considered to be the most likely diagnosis.

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