Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis

We report a case of glomerulopathy in a 36-year-old Japanese woman with primary Sjögren syndrome (pSS). The first renal biopsy suggested membranous glomerulonephritis. However, repeat biopsy was performed after 16 years because of increased proteinuria, revealing membranoproliferative glomerulonephr...

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Autores principales: Yabuuchi, Junko, Suwabe, Tatsuya, Ueno, Toshiharu, Hoshino, Junichi, Sekine, Akinari, Hayami, Noriko, Oguro, Masahiko, Kunisawa, Kyohei, Kawada, Masahiro, Yamanouchi, Masayuki, Sumida, Keiichi, Mizuno, Hiroki, Hasegawa, Eiko, Sawa, Naoki, Takaichi, Kenmei, Ohashi, Kenichi, Fujii, Takeshi, Ubara, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126589/
https://www.ncbi.nlm.nih.gov/pubmed/27904866
http://dx.doi.org/10.1159/000452298
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author Yabuuchi, Junko
Suwabe, Tatsuya
Ueno, Toshiharu
Hoshino, Junichi
Sekine, Akinari
Hayami, Noriko
Oguro, Masahiko
Kunisawa, Kyohei
Kawada, Masahiro
Yamanouchi, Masayuki
Sumida, Keiichi
Mizuno, Hiroki
Hasegawa, Eiko
Sawa, Naoki
Takaichi, Kenmei
Ohashi, Kenichi
Fujii, Takeshi
Ubara, Yoshifumi
author_facet Yabuuchi, Junko
Suwabe, Tatsuya
Ueno, Toshiharu
Hoshino, Junichi
Sekine, Akinari
Hayami, Noriko
Oguro, Masahiko
Kunisawa, Kyohei
Kawada, Masahiro
Yamanouchi, Masayuki
Sumida, Keiichi
Mizuno, Hiroki
Hasegawa, Eiko
Sawa, Naoki
Takaichi, Kenmei
Ohashi, Kenichi
Fujii, Takeshi
Ubara, Yoshifumi
author_sort Yabuuchi, Junko
collection PubMed
description We report a case of glomerulopathy in a 36-year-old Japanese woman with primary Sjögren syndrome (pSS). The first renal biopsy suggested membranous glomerulonephritis. However, repeat biopsy was performed after 16 years because of increased proteinuria, revealing membranoproliferative glomerulonephritis with mesangial deposits, subendothelial deposits, and subepithelial deposits. Immunofluorescent studies showed predominant deposition of IgG2 and IgG4. This patient was positive for antinuclear antibody and anti-SS-A antibody. Sicca syndrome was confirmed by a positive Schirmer test and positive Rose Bengal test. Therefore, pSS-related glomerulopathy was considered to be the most likely diagnosis.
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spelling pubmed-51265892016-11-30 Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis Yabuuchi, Junko Suwabe, Tatsuya Ueno, Toshiharu Hoshino, Junichi Sekine, Akinari Hayami, Noriko Oguro, Masahiko Kunisawa, Kyohei Kawada, Masahiro Yamanouchi, Masayuki Sumida, Keiichi Mizuno, Hiroki Hasegawa, Eiko Sawa, Naoki Takaichi, Kenmei Ohashi, Kenichi Fujii, Takeshi Ubara, Yoshifumi Case Rep Nephrol Dial Case Report We report a case of glomerulopathy in a 36-year-old Japanese woman with primary Sjögren syndrome (pSS). The first renal biopsy suggested membranous glomerulonephritis. However, repeat biopsy was performed after 16 years because of increased proteinuria, revealing membranoproliferative glomerulonephritis with mesangial deposits, subendothelial deposits, and subepithelial deposits. Immunofluorescent studies showed predominant deposition of IgG2 and IgG4. This patient was positive for antinuclear antibody and anti-SS-A antibody. Sicca syndrome was confirmed by a positive Schirmer test and positive Rose Bengal test. Therefore, pSS-related glomerulopathy was considered to be the most likely diagnosis. S. Karger AG 2016-11-14 /pmc/articles/PMC5126589/ /pubmed/27904866 http://dx.doi.org/10.1159/000452298 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Yabuuchi, Junko
Suwabe, Tatsuya
Ueno, Toshiharu
Hoshino, Junichi
Sekine, Akinari
Hayami, Noriko
Oguro, Masahiko
Kunisawa, Kyohei
Kawada, Masahiro
Yamanouchi, Masayuki
Sumida, Keiichi
Mizuno, Hiroki
Hasegawa, Eiko
Sawa, Naoki
Takaichi, Kenmei
Ohashi, Kenichi
Fujii, Takeshi
Ubara, Yoshifumi
Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis
title Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis
title_full Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis
title_fullStr Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis
title_full_unstemmed Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis
title_short Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis
title_sort sjögren syndrome-related membranous glomerulonephritis progressing to membranoproliferative glomerulonephritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126589/
https://www.ncbi.nlm.nih.gov/pubmed/27904866
http://dx.doi.org/10.1159/000452298
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