Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose

Methotrexate (MTX) is an antifolic drug used in the treatment of immune-mediated and neoplastic diseases. Initiation or dosage changes in MTX therapy can cause mucositis and bone marrow suppression. Skin lesions due to acute MTX toxicity are rare, but they serve as a herald for later-onset pancytope...

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Detalles Bibliográficos
Autores principales: Knoll, Katharina, Anzengruber, Florian, Cozzio, Antonio, French, Lars E., Murer, Carla, Navarini, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126609/
https://www.ncbi.nlm.nih.gov/pubmed/27920680
http://dx.doi.org/10.1159/000446692
Descripción
Sumario:Methotrexate (MTX) is an antifolic drug used in the treatment of immune-mediated and neoplastic diseases. Initiation or dosage changes in MTX therapy can cause mucositis and bone marrow suppression. Skin lesions due to acute MTX toxicity are rare, but they serve as a herald for later-onset pancytopenia. Therefore, identification of those cutaneous lesions might help to initiate rescue strategies at an early stage. Here we describe a case with mucocutaneous ulcerations and pancytopenia due to overdosed MTX.

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