Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose

Methotrexate (MTX) is an antifolic drug used in the treatment of immune-mediated and neoplastic diseases. Initiation or dosage changes in MTX therapy can cause mucositis and bone marrow suppression. Skin lesions due to acute MTX toxicity are rare, but they serve as a herald for later-onset pancytope...

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Autores principales: Knoll, Katharina, Anzengruber, Florian, Cozzio, Antonio, French, Lars E., Murer, Carla, Navarini, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126609/
https://www.ncbi.nlm.nih.gov/pubmed/27920680
http://dx.doi.org/10.1159/000446692
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author Knoll, Katharina
Anzengruber, Florian
Cozzio, Antonio
French, Lars E.
Murer, Carla
Navarini, Alexander A.
author_facet Knoll, Katharina
Anzengruber, Florian
Cozzio, Antonio
French, Lars E.
Murer, Carla
Navarini, Alexander A.
author_sort Knoll, Katharina
collection PubMed
description Methotrexate (MTX) is an antifolic drug used in the treatment of immune-mediated and neoplastic diseases. Initiation or dosage changes in MTX therapy can cause mucositis and bone marrow suppression. Skin lesions due to acute MTX toxicity are rare, but they serve as a herald for later-onset pancytopenia. Therefore, identification of those cutaneous lesions might help to initiate rescue strategies at an early stage. Here we describe a case with mucocutaneous ulcerations and pancytopenia due to overdosed MTX.
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spelling pubmed-51266092016-12-05 Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose Knoll, Katharina Anzengruber, Florian Cozzio, Antonio French, Lars E. Murer, Carla Navarini, Alexander A. Case Rep Dermatol Single Case Methotrexate (MTX) is an antifolic drug used in the treatment of immune-mediated and neoplastic diseases. Initiation or dosage changes in MTX therapy can cause mucositis and bone marrow suppression. Skin lesions due to acute MTX toxicity are rare, but they serve as a herald for later-onset pancytopenia. Therefore, identification of those cutaneous lesions might help to initiate rescue strategies at an early stage. Here we describe a case with mucocutaneous ulcerations and pancytopenia due to overdosed MTX. S. Karger AG 2016-11-07 /pmc/articles/PMC5126609/ /pubmed/27920680 http://dx.doi.org/10.1159/000446692 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Knoll, Katharina
Anzengruber, Florian
Cozzio, Antonio
French, Lars E.
Murer, Carla
Navarini, Alexander A.
Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose
title Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose
title_full Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose
title_fullStr Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose
title_full_unstemmed Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose
title_short Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose
title_sort mucocutaneous ulcerations and pancytopenia due to methotrexate overdose
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126609/
https://www.ncbi.nlm.nih.gov/pubmed/27920680
http://dx.doi.org/10.1159/000446692
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