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B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes
B cells have been strongly implicated in the development of human type 1 diabetes and are required for disease in the NOD mouse model. These functions are dependent on B cell antigen receptor (BCR) specificity and expression of MHC, implicating linked autoantigen recognition and presentation to effe...
Autores principales: | Packard, Thomas A., Smith, Mia J., Conrad, Francis J., Johnson, Sara A., Getahun, Andrew, Lindsay, Robin S., Hinman, Rochelle M., Friedman, Rachel S., Thomas, James W., Cambier, John C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126795/ https://www.ncbi.nlm.nih.gov/pubmed/27834793 http://dx.doi.org/10.3390/jcm5110098 |
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