Pleural inhibition of the caspase-1/IL-1β pathway diminishes profibrotic lung toxicity of bleomycin

BACKGROUND: Idiopathic and toxic pulmonary fibrosis are severe diseases starting classically in the subpleural area of the lung. It has recently been suggested that pleural mesothelial cells acquire a myofibroblast phenotype under fibrotic conditions induced by TGF-β1 or bleomycin. The importance an...

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Detalles Bibliográficos
Autores principales: Burgy, Olivier, Bellaye, Pierre-Simon, Causse, Sebastien, Beltramo, Guillaume, Wettstein, Guillaume, Boutanquoi, Pierre-Marie, Goirand, Françoise, Garrido, Carmen, Bonniaud, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127006/
https://www.ncbi.nlm.nih.gov/pubmed/27894300
http://dx.doi.org/10.1186/s12931-016-0475-8

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