Towards Engineering Novel PE-Based Immunotoxins by Targeting Them to the Nucleus

Exotoxin A (PE) from Pseudomonas aeruginosa is a bacterial ADP-ribosyltransferase, which can permanently inhibit translation in the attacked cells. Consequently, this toxin is frequently used in immunotoxins for targeted cancer therapies. In this study, we propose a novel modification to PE by incor...

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Detalles Bibliográficos
Autores principales: Borowiec, Marta, Gorzkiewicz, Michal, Grzesik, Joanna, Walczak-Drzewiecka, Aurelia, Salkowska, Anna, Rodakowska, Ewelina, Steczkiewicz, Kamil, Rychlewski, Leszek, Dastych, Jaroslaw, Ginalski, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127118/
https://www.ncbi.nlm.nih.gov/pubmed/27834892
http://dx.doi.org/10.3390/toxins8110321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127118/
https://www.ncbi.nlm.nih.gov/pubmed/27834892
http://dx.doi.org/10.3390/toxins8110321

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