N-methyl-2-pyridone-5-carboxamide (2PY)—Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin

N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new potential uremic toxicities of 2PY. In the context of...

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Detalles Bibliográficos
Autores principales: Lenglet, Aurélie, Liabeuf, Sophie, Bodeau, Sandra, Louvet, Loïc, Mary, Aurélien, Boullier, Agnès, Lemaire-Hurtel, Anne Sophie, Jonet, Alexia, Sonnet, Pascal, Kamel, Said, Massy, Ziad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127135/
https://www.ncbi.nlm.nih.gov/pubmed/27854278
http://dx.doi.org/10.3390/toxins8110339
Descripción
Sumario:N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new potential uremic toxicities of 2PY. In the context of uremia, the accumulation of 2PY could be harmful—perhaps by inhibiting poly (ADP-ribose) polymerase-1 activity. Here, we review recently published data on 2PY’s metabolism and toxicological profile.

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