N-methyl-2-pyridone-5-carboxamide (2PY)—Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin

N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new potential uremic toxicities of 2PY. In the context of...

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Autores principales: Lenglet, Aurélie, Liabeuf, Sophie, Bodeau, Sandra, Louvet, Loïc, Mary, Aurélien, Boullier, Agnès, Lemaire-Hurtel, Anne Sophie, Jonet, Alexia, Sonnet, Pascal, Kamel, Said, Massy, Ziad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127135/
https://www.ncbi.nlm.nih.gov/pubmed/27854278
http://dx.doi.org/10.3390/toxins8110339
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author Lenglet, Aurélie
Liabeuf, Sophie
Bodeau, Sandra
Louvet, Loïc
Mary, Aurélien
Boullier, Agnès
Lemaire-Hurtel, Anne Sophie
Jonet, Alexia
Sonnet, Pascal
Kamel, Said
Massy, Ziad A.
author_facet Lenglet, Aurélie
Liabeuf, Sophie
Bodeau, Sandra
Louvet, Loïc
Mary, Aurélien
Boullier, Agnès
Lemaire-Hurtel, Anne Sophie
Jonet, Alexia
Sonnet, Pascal
Kamel, Said
Massy, Ziad A.
author_sort Lenglet, Aurélie
collection PubMed
description N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new potential uremic toxicities of 2PY. In the context of uremia, the accumulation of 2PY could be harmful—perhaps by inhibiting poly (ADP-ribose) polymerase-1 activity. Here, we review recently published data on 2PY’s metabolism and toxicological profile.
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spelling pubmed-51271352016-12-02 N-methyl-2-pyridone-5-carboxamide (2PY)—Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin Lenglet, Aurélie Liabeuf, Sophie Bodeau, Sandra Louvet, Loïc Mary, Aurélien Boullier, Agnès Lemaire-Hurtel, Anne Sophie Jonet, Alexia Sonnet, Pascal Kamel, Said Massy, Ziad A. Toxins (Basel) Review N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new potential uremic toxicities of 2PY. In the context of uremia, the accumulation of 2PY could be harmful—perhaps by inhibiting poly (ADP-ribose) polymerase-1 activity. Here, we review recently published data on 2PY’s metabolism and toxicological profile. MDPI 2016-11-15 /pmc/articles/PMC5127135/ /pubmed/27854278 http://dx.doi.org/10.3390/toxins8110339 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lenglet, Aurélie
Liabeuf, Sophie
Bodeau, Sandra
Louvet, Loïc
Mary, Aurélien
Boullier, Agnès
Lemaire-Hurtel, Anne Sophie
Jonet, Alexia
Sonnet, Pascal
Kamel, Said
Massy, Ziad A.
N-methyl-2-pyridone-5-carboxamide (2PY)—Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin
title N-methyl-2-pyridone-5-carboxamide (2PY)—Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin
title_full N-methyl-2-pyridone-5-carboxamide (2PY)—Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin
title_fullStr N-methyl-2-pyridone-5-carboxamide (2PY)—Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin
title_full_unstemmed N-methyl-2-pyridone-5-carboxamide (2PY)—Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin
title_short N-methyl-2-pyridone-5-carboxamide (2PY)—Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin
title_sort n-methyl-2-pyridone-5-carboxamide (2py)—major metabolite of nicotinamide: an update on an old uremic toxin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127135/
https://www.ncbi.nlm.nih.gov/pubmed/27854278
http://dx.doi.org/10.3390/toxins8110339
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