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Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals

Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped...

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Autores principales: Paré, Pamela, Paixão-Côrtes, Vanessa R., Tovo-Rodrigues, Luciana, Vargas-Pinilla, Pedro, Viscardi, Lucas Henriques, Salzano, Francisco Mauro, Henkes, Luiz E., Bortolini, Maria Catira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127151/
https://www.ncbi.nlm.nih.gov/pubmed/27505307
http://dx.doi.org/10.1590/1678-4685-GMB-2015-0323
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author Paré, Pamela
Paixão-Côrtes, Vanessa R.
Tovo-Rodrigues, Luciana
Vargas-Pinilla, Pedro
Viscardi, Lucas Henriques
Salzano, Francisco Mauro
Henkes, Luiz E.
Bortolini, Maria Catira
author_facet Paré, Pamela
Paixão-Côrtes, Vanessa R.
Tovo-Rodrigues, Luciana
Vargas-Pinilla, Pedro
Viscardi, Lucas Henriques
Salzano, Francisco Mauro
Henkes, Luiz E.
Bortolini, Maria Catira
author_sort Paré, Pamela
collection PubMed
description Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped these four genes in placental mammals and to reveal specific aspects of their protein structures, 35 species were selected. Specifically, we investigated their molecular evolutionary history and intrinsic protein disorder content, and identified the presence of short linear interaction motifs. OXTR seems to be under evolutionary constraint in placental mammals, whereas AVPR1a, AVPR1b, and AVPR2 exhibit higher evolutionary rates, suggesting that they have been under relaxed or experienced positive selection. In addition, we describe here, for the first time, that the OXTR, AVPR1a, AVPR1b, and AVPR2 mammalian orthologues preserve their disorder content, while this condition varies among the paralogues. Finally, our results reveal the presence of short linear interaction motifs, indicating possible functional adaptations related to physiological and/or behavioral taxa-specific traits.
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spelling pubmed-51271512016-12-08 Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals Paré, Pamela Paixão-Côrtes, Vanessa R. Tovo-Rodrigues, Luciana Vargas-Pinilla, Pedro Viscardi, Lucas Henriques Salzano, Francisco Mauro Henkes, Luiz E. Bortolini, Maria Catira Genet Mol Biol Evolutionary Genetics Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped these four genes in placental mammals and to reveal specific aspects of their protein structures, 35 species were selected. Specifically, we investigated their molecular evolutionary history and intrinsic protein disorder content, and identified the presence of short linear interaction motifs. OXTR seems to be under evolutionary constraint in placental mammals, whereas AVPR1a, AVPR1b, and AVPR2 exhibit higher evolutionary rates, suggesting that they have been under relaxed or experienced positive selection. In addition, we describe here, for the first time, that the OXTR, AVPR1a, AVPR1b, and AVPR2 mammalian orthologues preserve their disorder content, while this condition varies among the paralogues. Finally, our results reveal the presence of short linear interaction motifs, indicating possible functional adaptations related to physiological and/or behavioral taxa-specific traits. Sociedade Brasileira de Genética 2016-08-08 2016 /pmc/articles/PMC5127151/ /pubmed/27505307 http://dx.doi.org/10.1590/1678-4685-GMB-2015-0323 Text en Copyright © 2016, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Evolutionary Genetics
Paré, Pamela
Paixão-Côrtes, Vanessa R.
Tovo-Rodrigues, Luciana
Vargas-Pinilla, Pedro
Viscardi, Lucas Henriques
Salzano, Francisco Mauro
Henkes, Luiz E.
Bortolini, Maria Catira
Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals
title Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals
title_full Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals
title_fullStr Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals
title_full_unstemmed Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals
title_short Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals
title_sort oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals
topic Evolutionary Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127151/
https://www.ncbi.nlm.nih.gov/pubmed/27505307
http://dx.doi.org/10.1590/1678-4685-GMB-2015-0323
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