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Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals
Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sociedade Brasileira de Genética
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127151/ https://www.ncbi.nlm.nih.gov/pubmed/27505307 http://dx.doi.org/10.1590/1678-4685-GMB-2015-0323 |
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author | Paré, Pamela Paixão-Côrtes, Vanessa R. Tovo-Rodrigues, Luciana Vargas-Pinilla, Pedro Viscardi, Lucas Henriques Salzano, Francisco Mauro Henkes, Luiz E. Bortolini, Maria Catira |
author_facet | Paré, Pamela Paixão-Côrtes, Vanessa R. Tovo-Rodrigues, Luciana Vargas-Pinilla, Pedro Viscardi, Lucas Henriques Salzano, Francisco Mauro Henkes, Luiz E. Bortolini, Maria Catira |
author_sort | Paré, Pamela |
collection | PubMed |
description | Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped these four genes in placental mammals and to reveal specific aspects of their protein structures, 35 species were selected. Specifically, we investigated their molecular evolutionary history and intrinsic protein disorder content, and identified the presence of short linear interaction motifs. OXTR seems to be under evolutionary constraint in placental mammals, whereas AVPR1a, AVPR1b, and AVPR2 exhibit higher evolutionary rates, suggesting that they have been under relaxed or experienced positive selection. In addition, we describe here, for the first time, that the OXTR, AVPR1a, AVPR1b, and AVPR2 mammalian orthologues preserve their disorder content, while this condition varies among the paralogues. Finally, our results reveal the presence of short linear interaction motifs, indicating possible functional adaptations related to physiological and/or behavioral taxa-specific traits. |
format | Online Article Text |
id | pubmed-5127151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Sociedade Brasileira de Genética |
record_format | MEDLINE/PubMed |
spelling | pubmed-51271512016-12-08 Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals Paré, Pamela Paixão-Côrtes, Vanessa R. Tovo-Rodrigues, Luciana Vargas-Pinilla, Pedro Viscardi, Lucas Henriques Salzano, Francisco Mauro Henkes, Luiz E. Bortolini, Maria Catira Genet Mol Biol Evolutionary Genetics Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped these four genes in placental mammals and to reveal specific aspects of their protein structures, 35 species were selected. Specifically, we investigated their molecular evolutionary history and intrinsic protein disorder content, and identified the presence of short linear interaction motifs. OXTR seems to be under evolutionary constraint in placental mammals, whereas AVPR1a, AVPR1b, and AVPR2 exhibit higher evolutionary rates, suggesting that they have been under relaxed or experienced positive selection. In addition, we describe here, for the first time, that the OXTR, AVPR1a, AVPR1b, and AVPR2 mammalian orthologues preserve their disorder content, while this condition varies among the paralogues. Finally, our results reveal the presence of short linear interaction motifs, indicating possible functional adaptations related to physiological and/or behavioral taxa-specific traits. Sociedade Brasileira de Genética 2016-08-08 2016 /pmc/articles/PMC5127151/ /pubmed/27505307 http://dx.doi.org/10.1590/1678-4685-GMB-2015-0323 Text en Copyright © 2016, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited. |
spellingShingle | Evolutionary Genetics Paré, Pamela Paixão-Côrtes, Vanessa R. Tovo-Rodrigues, Luciana Vargas-Pinilla, Pedro Viscardi, Lucas Henriques Salzano, Francisco Mauro Henkes, Luiz E. Bortolini, Maria Catira Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals |
title | Oxytocin and arginine vasopressin receptor evolution: implications for
adaptive novelties in placental mammals |
title_full | Oxytocin and arginine vasopressin receptor evolution: implications for
adaptive novelties in placental mammals |
title_fullStr | Oxytocin and arginine vasopressin receptor evolution: implications for
adaptive novelties in placental mammals |
title_full_unstemmed | Oxytocin and arginine vasopressin receptor evolution: implications for
adaptive novelties in placental mammals |
title_short | Oxytocin and arginine vasopressin receptor evolution: implications for
adaptive novelties in placental mammals |
title_sort | oxytocin and arginine vasopressin receptor evolution: implications for
adaptive novelties in placental mammals |
topic | Evolutionary Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127151/ https://www.ncbi.nlm.nih.gov/pubmed/27505307 http://dx.doi.org/10.1590/1678-4685-GMB-2015-0323 |
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