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Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies

Prospective epidemiologic studies that investigated the association between body mass index (BMI) and non-melanoma skin cancer (NMSC) yielded inconsistent findings. A dose-response meta-analysis was conducted to quantitatively summarize the evidence. PubMed and Embase databases were searched for rel...

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Autores principales: Zhou, Daijun, Wu, Jun, Luo, Gaoxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127294/
https://www.ncbi.nlm.nih.gov/pubmed/27898109
http://dx.doi.org/10.1038/srep37691
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author Zhou, Daijun
Wu, Jun
Luo, Gaoxing
author_facet Zhou, Daijun
Wu, Jun
Luo, Gaoxing
author_sort Zhou, Daijun
collection PubMed
description Prospective epidemiologic studies that investigated the association between body mass index (BMI) and non-melanoma skin cancer (NMSC) yielded inconsistent findings. A dose-response meta-analysis was conducted to quantitatively summarize the evidence. PubMed and Embase databases were searched for relevant studies. Study-specific relative risk (RR) and 95% confidence interval (CI) for an increase in BMI of 5 kg/m(2) was computed with the generalized least squares trend estimation, and these risk estimates were combined with the random-effects model. Nine publications were included in the final analyses, consisting of 18 independent cohorts with 22 risk estimates (971,795 participants and 50,561 NMSC cases). Results of the dose-response analyses showed a nonlinear inverse relationship between BMI and NMSC (RR = 0.88, 95% CI: 0.85–0.91, I(2) = 71.2%, P-nonlinearity <0.001), which persisted when limiting to the studies with adjustment for important potential confounders including sun exposure and sensitivity factors. The risk estimates were very similar for squamous cell carcinoma and basal cell carcinoma. Sex appeared a source of heterogeneity (P-difference = 0.06), with a weaker, but still significant inverse association in men than in women. This dose-response meta-analysis suggests a nonlinear inverse association between BMI and NMSC.
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spelling pubmed-51272942016-12-09 Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies Zhou, Daijun Wu, Jun Luo, Gaoxing Sci Rep Article Prospective epidemiologic studies that investigated the association between body mass index (BMI) and non-melanoma skin cancer (NMSC) yielded inconsistent findings. A dose-response meta-analysis was conducted to quantitatively summarize the evidence. PubMed and Embase databases were searched for relevant studies. Study-specific relative risk (RR) and 95% confidence interval (CI) for an increase in BMI of 5 kg/m(2) was computed with the generalized least squares trend estimation, and these risk estimates were combined with the random-effects model. Nine publications were included in the final analyses, consisting of 18 independent cohorts with 22 risk estimates (971,795 participants and 50,561 NMSC cases). Results of the dose-response analyses showed a nonlinear inverse relationship between BMI and NMSC (RR = 0.88, 95% CI: 0.85–0.91, I(2) = 71.2%, P-nonlinearity <0.001), which persisted when limiting to the studies with adjustment for important potential confounders including sun exposure and sensitivity factors. The risk estimates were very similar for squamous cell carcinoma and basal cell carcinoma. Sex appeared a source of heterogeneity (P-difference = 0.06), with a weaker, but still significant inverse association in men than in women. This dose-response meta-analysis suggests a nonlinear inverse association between BMI and NMSC. Nature Publishing Group 2016-11-29 /pmc/articles/PMC5127294/ /pubmed/27898109 http://dx.doi.org/10.1038/srep37691 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhou, Daijun
Wu, Jun
Luo, Gaoxing
Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies
title Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies
title_full Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies
title_fullStr Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies
title_full_unstemmed Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies
title_short Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies
title_sort body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127294/
https://www.ncbi.nlm.nih.gov/pubmed/27898109
http://dx.doi.org/10.1038/srep37691
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