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Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies
Prospective epidemiologic studies that investigated the association between body mass index (BMI) and non-melanoma skin cancer (NMSC) yielded inconsistent findings. A dose-response meta-analysis was conducted to quantitatively summarize the evidence. PubMed and Embase databases were searched for rel...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127294/ https://www.ncbi.nlm.nih.gov/pubmed/27898109 http://dx.doi.org/10.1038/srep37691 |
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author | Zhou, Daijun Wu, Jun Luo, Gaoxing |
author_facet | Zhou, Daijun Wu, Jun Luo, Gaoxing |
author_sort | Zhou, Daijun |
collection | PubMed |
description | Prospective epidemiologic studies that investigated the association between body mass index (BMI) and non-melanoma skin cancer (NMSC) yielded inconsistent findings. A dose-response meta-analysis was conducted to quantitatively summarize the evidence. PubMed and Embase databases were searched for relevant studies. Study-specific relative risk (RR) and 95% confidence interval (CI) for an increase in BMI of 5 kg/m(2) was computed with the generalized least squares trend estimation, and these risk estimates were combined with the random-effects model. Nine publications were included in the final analyses, consisting of 18 independent cohorts with 22 risk estimates (971,795 participants and 50,561 NMSC cases). Results of the dose-response analyses showed a nonlinear inverse relationship between BMI and NMSC (RR = 0.88, 95% CI: 0.85–0.91, I(2) = 71.2%, P-nonlinearity <0.001), which persisted when limiting to the studies with adjustment for important potential confounders including sun exposure and sensitivity factors. The risk estimates were very similar for squamous cell carcinoma and basal cell carcinoma. Sex appeared a source of heterogeneity (P-difference = 0.06), with a weaker, but still significant inverse association in men than in women. This dose-response meta-analysis suggests a nonlinear inverse association between BMI and NMSC. |
format | Online Article Text |
id | pubmed-5127294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51272942016-12-09 Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies Zhou, Daijun Wu, Jun Luo, Gaoxing Sci Rep Article Prospective epidemiologic studies that investigated the association between body mass index (BMI) and non-melanoma skin cancer (NMSC) yielded inconsistent findings. A dose-response meta-analysis was conducted to quantitatively summarize the evidence. PubMed and Embase databases were searched for relevant studies. Study-specific relative risk (RR) and 95% confidence interval (CI) for an increase in BMI of 5 kg/m(2) was computed with the generalized least squares trend estimation, and these risk estimates were combined with the random-effects model. Nine publications were included in the final analyses, consisting of 18 independent cohorts with 22 risk estimates (971,795 participants and 50,561 NMSC cases). Results of the dose-response analyses showed a nonlinear inverse relationship between BMI and NMSC (RR = 0.88, 95% CI: 0.85–0.91, I(2) = 71.2%, P-nonlinearity <0.001), which persisted when limiting to the studies with adjustment for important potential confounders including sun exposure and sensitivity factors. The risk estimates were very similar for squamous cell carcinoma and basal cell carcinoma. Sex appeared a source of heterogeneity (P-difference = 0.06), with a weaker, but still significant inverse association in men than in women. This dose-response meta-analysis suggests a nonlinear inverse association between BMI and NMSC. Nature Publishing Group 2016-11-29 /pmc/articles/PMC5127294/ /pubmed/27898109 http://dx.doi.org/10.1038/srep37691 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Zhou, Daijun Wu, Jun Luo, Gaoxing Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies |
title | Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies |
title_full | Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies |
title_fullStr | Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies |
title_full_unstemmed | Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies |
title_short | Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies |
title_sort | body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127294/ https://www.ncbi.nlm.nih.gov/pubmed/27898109 http://dx.doi.org/10.1038/srep37691 |
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