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Mortality in HIV-Infected Alcohol and Drug Users in St. Petersburg, Russia
In Russia, up to half of premature deaths are attributed to hazardous drinking. The respective roles of alcohol and drug use in premature death among people with HIV in Russia have not been described. Criminalization and stigmatization of substance use in Russia may also contribute to mortality. We...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127495/ https://www.ncbi.nlm.nih.gov/pubmed/27898683 http://dx.doi.org/10.1371/journal.pone.0166539 |
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author | Fairbairn, Nadia S. Walley, Alexander Y. Cheng, Debbie M. Quinn, Emily Bridden, Carly Chaisson, Christine Blokhina, Elena Lioznov, Dmitry Krupitsky, Evgeny Raj, Anita Samet, Jeffrey H. |
author_facet | Fairbairn, Nadia S. Walley, Alexander Y. Cheng, Debbie M. Quinn, Emily Bridden, Carly Chaisson, Christine Blokhina, Elena Lioznov, Dmitry Krupitsky, Evgeny Raj, Anita Samet, Jeffrey H. |
author_sort | Fairbairn, Nadia S. |
collection | PubMed |
description | In Russia, up to half of premature deaths are attributed to hazardous drinking. The respective roles of alcohol and drug use in premature death among people with HIV in Russia have not been described. Criminalization and stigmatization of substance use in Russia may also contribute to mortality. We explored whether alcohol, drug use and risk environment factors are associated with short-term mortality in HIV-infected Russians who use substances. Secondary analyses were conducted using prospective data collected at baseline, 6 and 12-months from HIV-infected people who use substances recruited between 2007–2010 from addiction and HIV care settings in a single urban setting of St. Petersburg, Russia. We used Cox proportional hazards models to explore associations between 30-day alcohol hazardous drinking, injection drug use, polysubstance use and environmental risk exposures (i.e. past incarceration, police involvement, selling sex, and HIV stigma) with mortality. Among 700 participants, 59% were male and the mean age was 30 years. There were 40 deaths after a median follow-up of 12 months (crude mortality rate 5.9 per 100 person-years). In adjusted analyses, 30-day NIAAA hazardous drinking was significantly associated with mortality compared to no drinking [adjusted Hazard Ratio (aHR) 2.60, 95% Confidence Interval (CI): 1.24–5.44] but moderate drinking was not (aHR 0.95, 95% CI: 0.35–2.59). No other factors were significantly associated with mortality. The high rates of short-term mortality and the strong association with hazardous drinking suggest a need to integrate evidence-based alcohol interventions into treatment strategies for HIV-infected Russians. |
format | Online Article Text |
id | pubmed-5127495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-51274952016-12-15 Mortality in HIV-Infected Alcohol and Drug Users in St. Petersburg, Russia Fairbairn, Nadia S. Walley, Alexander Y. Cheng, Debbie M. Quinn, Emily Bridden, Carly Chaisson, Christine Blokhina, Elena Lioznov, Dmitry Krupitsky, Evgeny Raj, Anita Samet, Jeffrey H. PLoS One Research Article In Russia, up to half of premature deaths are attributed to hazardous drinking. The respective roles of alcohol and drug use in premature death among people with HIV in Russia have not been described. Criminalization and stigmatization of substance use in Russia may also contribute to mortality. We explored whether alcohol, drug use and risk environment factors are associated with short-term mortality in HIV-infected Russians who use substances. Secondary analyses were conducted using prospective data collected at baseline, 6 and 12-months from HIV-infected people who use substances recruited between 2007–2010 from addiction and HIV care settings in a single urban setting of St. Petersburg, Russia. We used Cox proportional hazards models to explore associations between 30-day alcohol hazardous drinking, injection drug use, polysubstance use and environmental risk exposures (i.e. past incarceration, police involvement, selling sex, and HIV stigma) with mortality. Among 700 participants, 59% were male and the mean age was 30 years. There were 40 deaths after a median follow-up of 12 months (crude mortality rate 5.9 per 100 person-years). In adjusted analyses, 30-day NIAAA hazardous drinking was significantly associated with mortality compared to no drinking [adjusted Hazard Ratio (aHR) 2.60, 95% Confidence Interval (CI): 1.24–5.44] but moderate drinking was not (aHR 0.95, 95% CI: 0.35–2.59). No other factors were significantly associated with mortality. The high rates of short-term mortality and the strong association with hazardous drinking suggest a need to integrate evidence-based alcohol interventions into treatment strategies for HIV-infected Russians. Public Library of Science 2016-11-29 /pmc/articles/PMC5127495/ /pubmed/27898683 http://dx.doi.org/10.1371/journal.pone.0166539 Text en © 2016 Fairbairn et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Fairbairn, Nadia S. Walley, Alexander Y. Cheng, Debbie M. Quinn, Emily Bridden, Carly Chaisson, Christine Blokhina, Elena Lioznov, Dmitry Krupitsky, Evgeny Raj, Anita Samet, Jeffrey H. Mortality in HIV-Infected Alcohol and Drug Users in St. Petersburg, Russia |
title | Mortality in HIV-Infected Alcohol and Drug Users in St. Petersburg, Russia |
title_full | Mortality in HIV-Infected Alcohol and Drug Users in St. Petersburg, Russia |
title_fullStr | Mortality in HIV-Infected Alcohol and Drug Users in St. Petersburg, Russia |
title_full_unstemmed | Mortality in HIV-Infected Alcohol and Drug Users in St. Petersburg, Russia |
title_short | Mortality in HIV-Infected Alcohol and Drug Users in St. Petersburg, Russia |
title_sort | mortality in hiv-infected alcohol and drug users in st. petersburg, russia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127495/ https://www.ncbi.nlm.nih.gov/pubmed/27898683 http://dx.doi.org/10.1371/journal.pone.0166539 |
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