High-Resolution Phenotypic Landscape of the RNA Polymerase II Trigger Loop

The active sites of multisubunit RNA polymerases have a “trigger loop” (TL) that multitasks in substrate selection, catalysis, and translocation. To dissect the Saccharomyces cerevisiae RNA polymerase II TL at individual-residue resolution, we quantitatively phenotyped nearly all TL single variants...

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Detalles Bibliográficos
Autores principales: Qiu, Chenxi, Erinne, Olivia C., Dave, Jui M., Cui, Ping, Jin, Huiyan, Muthukrishnan, Nandhini, Tang, Leung K., Babu, Sabareesh Ganesh, Lam, Kenny C., Vandeventer, Paul J., Strohner, Ralf, Van den Brulle, Jan, Sze, Sing-Hoi, Kaplan, Craig D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127505/
https://www.ncbi.nlm.nih.gov/pubmed/27898685
http://dx.doi.org/10.1371/journal.pgen.1006321

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