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Identification of a Novel Inhibitory Allosteric Site in p38α

In the present study, we report the discovery of a novel allosteric inhibitory site for p38α, a subclass of the mitogen-activated protein kinases (MAPK) family. The putative site was discovered after inspection of the crystallographic structure of the p38α-MK2 complex. MK2 (MAPK-activated protein ki...

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Detalles Bibliográficos
Autores principales:	Gomez-Gutierrez, Patricia, Campos, Pedro M., Vega, Miguel, Perez, Juan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127581/ https://www.ncbi.nlm.nih.gov/pubmed/27898710 http://dx.doi.org/10.1371/journal.pone.0167379

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