Isoflurane Exposure Induces Cell Death, Microglial Activation and Modifies the Expression of Genes Supporting Neurodevelopment and Cognitive Function in the Male Newborn Piglet Brain

Exposure of the brain to general anesthesia during early infancy may adversely affect its neural and cognitive development. The mechanisms mediating this are complex, incompletely understood and may be sexually dimorphic, but include developmentally inappropriate apoptosis, inflammation and a disrup...

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Detalles Bibliográficos
Autores principales: Broad, Kevin D., Hassell, Jane, Fleiss, Bobbi, Kawano, Go, Ezzati, Mojgan, Rocha-Ferreira, Eridan, Hristova, Mariya, Bennett, Kate, Fierens, Igor, Burnett, Ryan, Chaban, Badr, Alonso-Alconada, Daniel, Oliver-Taylor, Aaron, Tachsidis, Ilias, Rostami, Jamshid, Gressens, Pierre, Sanders, Robert D., Robertson, Nicola J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127656/
https://www.ncbi.nlm.nih.gov/pubmed/27898690
http://dx.doi.org/10.1371/journal.pone.0166784

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