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Noise Decomposition Principle in a Coherent Feed-Forward Transcriptional Regulatory Loop
Coherent feed-forward loops exist extensively in realistic biological regulatory systems, and are common signaling motifs. Here, we study the characteristics and the propagation mechanism of the output noise in a coherent feed-forward transcriptional regulatory loop that can be divided into a main r...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127843/ https://www.ncbi.nlm.nih.gov/pubmed/27965596 http://dx.doi.org/10.3389/fphys.2016.00600 |
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author | Gui, Rong Liu, Quan Yao, Yuangen Deng, Haiyou Ma, Chengzhang Jia, Ya Yi, Ming |
author_facet | Gui, Rong Liu, Quan Yao, Yuangen Deng, Haiyou Ma, Chengzhang Jia, Ya Yi, Ming |
author_sort | Gui, Rong |
collection | PubMed |
description | Coherent feed-forward loops exist extensively in realistic biological regulatory systems, and are common signaling motifs. Here, we study the characteristics and the propagation mechanism of the output noise in a coherent feed-forward transcriptional regulatory loop that can be divided into a main road and branch. Using the linear noise approximation, we derive analytical formulae for the total noise of the full loop, the noise of the branch, and the noise of the main road, which are verified by the Gillespie algorithm. Importantly, we find that (i) compared with the branch motif or the main road motif, the full motif can effectively attenuate the output noise level; (ii) there is a transition point of system state such that the noise of the main road is dominated when the underlying system is below this point, whereas the noise of the branch is dominated when the system is beyond the point. The entire analysis reveals the mechanism of how the noise is generated and propagated in a simple yet representative signaling module. |
format | Online Article Text |
id | pubmed-5127843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51278432016-12-13 Noise Decomposition Principle in a Coherent Feed-Forward Transcriptional Regulatory Loop Gui, Rong Liu, Quan Yao, Yuangen Deng, Haiyou Ma, Chengzhang Jia, Ya Yi, Ming Front Physiol Physiology Coherent feed-forward loops exist extensively in realistic biological regulatory systems, and are common signaling motifs. Here, we study the characteristics and the propagation mechanism of the output noise in a coherent feed-forward transcriptional regulatory loop that can be divided into a main road and branch. Using the linear noise approximation, we derive analytical formulae for the total noise of the full loop, the noise of the branch, and the noise of the main road, which are verified by the Gillespie algorithm. Importantly, we find that (i) compared with the branch motif or the main road motif, the full motif can effectively attenuate the output noise level; (ii) there is a transition point of system state such that the noise of the main road is dominated when the underlying system is below this point, whereas the noise of the branch is dominated when the system is beyond the point. The entire analysis reveals the mechanism of how the noise is generated and propagated in a simple yet representative signaling module. Frontiers Media S.A. 2016-11-30 /pmc/articles/PMC5127843/ /pubmed/27965596 http://dx.doi.org/10.3389/fphys.2016.00600 Text en Copyright © 2016 Gui, Liu, Yao, Deng, Ma, Jia and Yi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Gui, Rong Liu, Quan Yao, Yuangen Deng, Haiyou Ma, Chengzhang Jia, Ya Yi, Ming Noise Decomposition Principle in a Coherent Feed-Forward Transcriptional Regulatory Loop |
title | Noise Decomposition Principle in a Coherent Feed-Forward Transcriptional Regulatory Loop |
title_full | Noise Decomposition Principle in a Coherent Feed-Forward Transcriptional Regulatory Loop |
title_fullStr | Noise Decomposition Principle in a Coherent Feed-Forward Transcriptional Regulatory Loop |
title_full_unstemmed | Noise Decomposition Principle in a Coherent Feed-Forward Transcriptional Regulatory Loop |
title_short | Noise Decomposition Principle in a Coherent Feed-Forward Transcriptional Regulatory Loop |
title_sort | noise decomposition principle in a coherent feed-forward transcriptional regulatory loop |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127843/ https://www.ncbi.nlm.nih.gov/pubmed/27965596 http://dx.doi.org/10.3389/fphys.2016.00600 |
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