Review of Osteosarcoma and Current Management

Osteosarcoma is the most common primary malignancy of bone in children and young adults. This tumor has a very heterogeneous genetic profile and lacks any consistent unifying event that leads to the pathogenesis of osteosarcoma. In this review, some of the important genetic events involved in osteos...

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Detalles Bibliográficos
Autores principales: Durfee, Ryan A., Mohammed, Maryam, Luu, Hue H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127970/
https://www.ncbi.nlm.nih.gov/pubmed/27761754
http://dx.doi.org/10.1007/s40744-016-0046-y
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author Durfee, Ryan A.
Mohammed, Maryam
Luu, Hue H.
author_facet Durfee, Ryan A.
Mohammed, Maryam
Luu, Hue H.
author_sort Durfee, Ryan A.
collection PubMed
description Osteosarcoma is the most common primary malignancy of bone in children and young adults. This tumor has a very heterogeneous genetic profile and lacks any consistent unifying event that leads to the pathogenesis of osteosarcoma. In this review, some of the important genetic events involved in osteosarcoma will be highlighted. Additionally, the clinical diagnosis of osteosarcoma will be discussed, as well as contemporary chemotherapeutic and surgical management of this tumor. Finally, the review will discuss some of the novel approaches to treating this disease.
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spelling pubmed-51279702016-12-19 Review of Osteosarcoma and Current Management Durfee, Ryan A. Mohammed, Maryam Luu, Hue H. Rheumatol Ther Review Osteosarcoma is the most common primary malignancy of bone in children and young adults. This tumor has a very heterogeneous genetic profile and lacks any consistent unifying event that leads to the pathogenesis of osteosarcoma. In this review, some of the important genetic events involved in osteosarcoma will be highlighted. Additionally, the clinical diagnosis of osteosarcoma will be discussed, as well as contemporary chemotherapeutic and surgical management of this tumor. Finally, the review will discuss some of the novel approaches to treating this disease. Springer Healthcare 2016-10-19 /pmc/articles/PMC5127970/ /pubmed/27761754 http://dx.doi.org/10.1007/s40744-016-0046-y Text en © The Author(s) 2016 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Durfee, Ryan A.
Mohammed, Maryam
Luu, Hue H.
Review of Osteosarcoma and Current Management
title Review of Osteosarcoma and Current Management
title_full Review of Osteosarcoma and Current Management
title_fullStr Review of Osteosarcoma and Current Management
title_full_unstemmed Review of Osteosarcoma and Current Management
title_short Review of Osteosarcoma and Current Management
title_sort review of osteosarcoma and current management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127970/
https://www.ncbi.nlm.nih.gov/pubmed/27761754
http://dx.doi.org/10.1007/s40744-016-0046-y
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