A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges

The Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that sever...

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Detalles Bibliográficos
Autores principales: Timmins, Joanna, Moe, Elin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2016
Materias:
Short Survey
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128194/
https://www.ncbi.nlm.nih.gov/pubmed/27924191
http://dx.doi.org/10.1016/j.csbj.2016.04.001
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author Timmins, Joanna
Moe, Elin
author_facet Timmins, Joanna
Moe, Elin
author_sort Timmins, Joanna
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description The Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that several factors contribute to this phenotype. Efficient scavenging of reactive oxygen species and repair of damaged DNA are two of these. In this review, we summarise the results from a decade of structural and functional studies of the DNA repair machinery of Deinococcus radiodurans and discuss how these studies have contributed to an improved understanding of the molecular mechanisms underlying DNA repair and to the outstanding resistance of Deinococcus radiodurans to DNA damaging agents.
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spelling pubmed-51281942016-12-06 A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges Timmins, Joanna Moe, Elin Comput Struct Biotechnol J Short Survey The Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that several factors contribute to this phenotype. Efficient scavenging of reactive oxygen species and repair of damaged DNA are two of these. In this review, we summarise the results from a decade of structural and functional studies of the DNA repair machinery of Deinococcus radiodurans and discuss how these studies have contributed to an improved understanding of the molecular mechanisms underlying DNA repair and to the outstanding resistance of Deinococcus radiodurans to DNA damaging agents. Research Network of Computational and Structural Biotechnology 2016-04-27 /pmc/articles/PMC5128194/ /pubmed/27924191 http://dx.doi.org/10.1016/j.csbj.2016.04.001 Text en © 2016 Natrix Separations http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Short Survey
Timmins, Joanna
Moe, Elin
A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges
title A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges
title_full A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges
title_fullStr A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges
title_full_unstemmed A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges
title_short A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges
title_sort decade of biochemical and structural studies of the dna repair machinery of deinococcus radiodurans: major findings, functional and mechanistic insight and challenges
topic Short Survey
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128194/
https://www.ncbi.nlm.nih.gov/pubmed/27924191
http://dx.doi.org/10.1016/j.csbj.2016.04.001
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