Cargando…
A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges
The Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that sever...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128194/ https://www.ncbi.nlm.nih.gov/pubmed/27924191 http://dx.doi.org/10.1016/j.csbj.2016.04.001 |
_version_ | 1782470355850362880 |
---|---|
author | Timmins, Joanna Moe, Elin |
author_facet | Timmins, Joanna Moe, Elin |
author_sort | Timmins, Joanna |
collection | PubMed |
description | The Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that several factors contribute to this phenotype. Efficient scavenging of reactive oxygen species and repair of damaged DNA are two of these. In this review, we summarise the results from a decade of structural and functional studies of the DNA repair machinery of Deinococcus radiodurans and discuss how these studies have contributed to an improved understanding of the molecular mechanisms underlying DNA repair and to the outstanding resistance of Deinococcus radiodurans to DNA damaging agents. |
format | Online Article Text |
id | pubmed-5128194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Research Network of Computational and Structural Biotechnology |
record_format | MEDLINE/PubMed |
spelling | pubmed-51281942016-12-06 A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges Timmins, Joanna Moe, Elin Comput Struct Biotechnol J Short Survey The Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that several factors contribute to this phenotype. Efficient scavenging of reactive oxygen species and repair of damaged DNA are two of these. In this review, we summarise the results from a decade of structural and functional studies of the DNA repair machinery of Deinococcus radiodurans and discuss how these studies have contributed to an improved understanding of the molecular mechanisms underlying DNA repair and to the outstanding resistance of Deinococcus radiodurans to DNA damaging agents. Research Network of Computational and Structural Biotechnology 2016-04-27 /pmc/articles/PMC5128194/ /pubmed/27924191 http://dx.doi.org/10.1016/j.csbj.2016.04.001 Text en © 2016 Natrix Separations http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Short Survey Timmins, Joanna Moe, Elin A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges |
title | A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges |
title_full | A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges |
title_fullStr | A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges |
title_full_unstemmed | A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges |
title_short | A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges |
title_sort | decade of biochemical and structural studies of the dna repair machinery of deinococcus radiodurans: major findings, functional and mechanistic insight and challenges |
topic | Short Survey |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128194/ https://www.ncbi.nlm.nih.gov/pubmed/27924191 http://dx.doi.org/10.1016/j.csbj.2016.04.001 |
work_keys_str_mv | AT timminsjoanna adecadeofbiochemicalandstructuralstudiesofthednarepairmachineryofdeinococcusradioduransmajorfindingsfunctionalandmechanisticinsightandchallenges AT moeelin adecadeofbiochemicalandstructuralstudiesofthednarepairmachineryofdeinococcusradioduransmajorfindingsfunctionalandmechanisticinsightandchallenges AT timminsjoanna decadeofbiochemicalandstructuralstudiesofthednarepairmachineryofdeinococcusradioduransmajorfindingsfunctionalandmechanisticinsightandchallenges AT moeelin decadeofbiochemicalandstructuralstudiesofthednarepairmachineryofdeinococcusradioduransmajorfindingsfunctionalandmechanisticinsightandchallenges |