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Association of Endoscopic Features of Gastric Mucosa with Helicobacter pylori Infection in Chinese Patients

The aim of this study is to identify and consolidate reliable endoscopic features associated with H. pylori infection in gastric mucosa, which is one of the major causes of gastric cancer. A total of 256 Chinese patients with symptomatic stomach disturbances were enrolled. Pathological examination w...

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Autores principales: Mao, Tao, Wang, Yan, Yin, Fan, Zhao, Qingxi, Yang, Lin, Ding, Xueli, Tian, Zibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128703/
https://www.ncbi.nlm.nih.gov/pubmed/27974885
http://dx.doi.org/10.1155/2016/6539639
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author Mao, Tao
Wang, Yan
Yin, Fan
Zhao, Qingxi
Yang, Lin
Ding, Xueli
Tian, Zibin
author_facet Mao, Tao
Wang, Yan
Yin, Fan
Zhao, Qingxi
Yang, Lin
Ding, Xueli
Tian, Zibin
author_sort Mao, Tao
collection PubMed
description The aim of this study is to identify and consolidate reliable endoscopic features associated with H. pylori infection in gastric mucosa, which is one of the major causes of gastric cancer. A total of 256 Chinese patients with symptomatic stomach disturbances were enrolled. Pathological examination was conducted using a light microscope and biopsy specimens stained with hematoxylin-eosin. Endoscopic examination was performed using a high resolution video endoscope. The association between endoscopic features and pathological H. pylori diagnosis was compared, and endoscopic features significantly associated with H. pylori infection were identified. A total of 14 endoscopic features were observed. Six of the 14 endoscopic features, including mucus on the gastric mucosa, diffuse redness, spotty redness of fundic mucosa, enlarged fold, mucosal edema, and RAC (type D and type I), were highly associated with H. pylori infection and were significantly sensitive and specific predictors for H. pylori diagnosis. The type R RAC was not significantly associated with H. pylori diagnosis. Our results indicate that conventional endoscopy features can be used to diagnose H. pylori in Chinese patients and can help determine the risk factor for gastric cancer.
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spelling pubmed-51287032016-12-14 Association of Endoscopic Features of Gastric Mucosa with Helicobacter pylori Infection in Chinese Patients Mao, Tao Wang, Yan Yin, Fan Zhao, Qingxi Yang, Lin Ding, Xueli Tian, Zibin Gastroenterol Res Pract Research Article The aim of this study is to identify and consolidate reliable endoscopic features associated with H. pylori infection in gastric mucosa, which is one of the major causes of gastric cancer. A total of 256 Chinese patients with symptomatic stomach disturbances were enrolled. Pathological examination was conducted using a light microscope and biopsy specimens stained with hematoxylin-eosin. Endoscopic examination was performed using a high resolution video endoscope. The association between endoscopic features and pathological H. pylori diagnosis was compared, and endoscopic features significantly associated with H. pylori infection were identified. A total of 14 endoscopic features were observed. Six of the 14 endoscopic features, including mucus on the gastric mucosa, diffuse redness, spotty redness of fundic mucosa, enlarged fold, mucosal edema, and RAC (type D and type I), were highly associated with H. pylori infection and were significantly sensitive and specific predictors for H. pylori diagnosis. The type R RAC was not significantly associated with H. pylori diagnosis. Our results indicate that conventional endoscopy features can be used to diagnose H. pylori in Chinese patients and can help determine the risk factor for gastric cancer. Hindawi Publishing Corporation 2016 2016-11-16 /pmc/articles/PMC5128703/ /pubmed/27974885 http://dx.doi.org/10.1155/2016/6539639 Text en Copyright © 2016 Tao Mao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mao, Tao
Wang, Yan
Yin, Fan
Zhao, Qingxi
Yang, Lin
Ding, Xueli
Tian, Zibin
Association of Endoscopic Features of Gastric Mucosa with Helicobacter pylori Infection in Chinese Patients
title Association of Endoscopic Features of Gastric Mucosa with Helicobacter pylori Infection in Chinese Patients
title_full Association of Endoscopic Features of Gastric Mucosa with Helicobacter pylori Infection in Chinese Patients
title_fullStr Association of Endoscopic Features of Gastric Mucosa with Helicobacter pylori Infection in Chinese Patients
title_full_unstemmed Association of Endoscopic Features of Gastric Mucosa with Helicobacter pylori Infection in Chinese Patients
title_short Association of Endoscopic Features of Gastric Mucosa with Helicobacter pylori Infection in Chinese Patients
title_sort association of endoscopic features of gastric mucosa with helicobacter pylori infection in chinese patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128703/
https://www.ncbi.nlm.nih.gov/pubmed/27974885
http://dx.doi.org/10.1155/2016/6539639
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