Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments †

The properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified as Biscogniauxia mediterranea based on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A n...

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Autores principales: Wu, Bin, Wiese, Jutta, Schmaljohann, Rolf, Imhoff, Johannes F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128747/
https://www.ncbi.nlm.nih.gov/pubmed/27827848
http://dx.doi.org/10.3390/md14110204
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author Wu, Bin
Wiese, Jutta
Schmaljohann, Rolf
Imhoff, Johannes F.
author_facet Wu, Bin
Wiese, Jutta
Schmaljohann, Rolf
Imhoff, Johannes F.
author_sort Wu, Bin
collection PubMed
description The properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified as Biscogniauxia mediterranea based on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A new isopyrrolonaphthoquinone with inhibitory activity against glycogen synthase kinase (GSK-3β) was isolated from this fungus. This is the first report of this class of compounds from a fungus isolated from a deep-sea sediment, as well as from a Biscogniauxia species.
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spelling pubmed-51287472016-12-06 Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments † Wu, Bin Wiese, Jutta Schmaljohann, Rolf Imhoff, Johannes F. Mar Drugs Article The properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified as Biscogniauxia mediterranea based on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A new isopyrrolonaphthoquinone with inhibitory activity against glycogen synthase kinase (GSK-3β) was isolated from this fungus. This is the first report of this class of compounds from a fungus isolated from a deep-sea sediment, as well as from a Biscogniauxia species. MDPI 2016-11-02 /pmc/articles/PMC5128747/ /pubmed/27827848 http://dx.doi.org/10.3390/md14110204 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Bin
Wiese, Jutta
Schmaljohann, Rolf
Imhoff, Johannes F.
Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments †
title Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments †
title_full Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments †
title_fullStr Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments †
title_full_unstemmed Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments †
title_short Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments †
title_sort biscogniauxone, a new isopyrrolonaphthoquinone compound from the fungus biscogniauxia mediterranea isolated from deep-sea sediments †
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128747/
https://www.ncbi.nlm.nih.gov/pubmed/27827848
http://dx.doi.org/10.3390/md14110204
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