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Alkynyl-Containing Peptides of Marine Origin: A Review

Since the 1990s, a number of terminal alkynyl residue-containing cyclic/acyclic peptides have been identified from marine organisms, especially cyanobacteria and marine mollusks. This review has presented 66 peptides, which covers over 90% marine peptides with terminal alkynyl fatty acyl units. In f...

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Autores principales: Chai, Qiu-Ye, Yang, Zhen, Lin, Hou-Wen, Han, Bing-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128759/
https://www.ncbi.nlm.nih.gov/pubmed/27886049
http://dx.doi.org/10.3390/md14110216
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author Chai, Qiu-Ye
Yang, Zhen
Lin, Hou-Wen
Han, Bing-Nan
author_facet Chai, Qiu-Ye
Yang, Zhen
Lin, Hou-Wen
Han, Bing-Nan
author_sort Chai, Qiu-Ye
collection PubMed
description Since the 1990s, a number of terminal alkynyl residue-containing cyclic/acyclic peptides have been identified from marine organisms, especially cyanobacteria and marine mollusks. This review has presented 66 peptides, which covers over 90% marine peptides with terminal alkynyl fatty acyl units. In fact, more than 90% of these peptides described in the literature are of cyanobacterial origin. Interestingly, all the linear peptides featured with terminal alkyne were solely discovered from marine cyanobacteria. The objective of this article is to provide an overview on the types, structural characterization of these unusual terminal alkynyl fatty acyl units, as well as the sources and biological functions of their composed peptides. Many of these peptides have a variety of biological activities, including antitumor, antibacterial, antimalarial, etc. Further, we have also discussed the evident biosynthetic origin responsible for formation of terminal alkynes of natural PKS (polyketide synthase)/NRPS (nonribosome peptide synthetase) hybrids.
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spelling pubmed-51287592016-12-06 Alkynyl-Containing Peptides of Marine Origin: A Review Chai, Qiu-Ye Yang, Zhen Lin, Hou-Wen Han, Bing-Nan Mar Drugs Review Since the 1990s, a number of terminal alkynyl residue-containing cyclic/acyclic peptides have been identified from marine organisms, especially cyanobacteria and marine mollusks. This review has presented 66 peptides, which covers over 90% marine peptides with terminal alkynyl fatty acyl units. In fact, more than 90% of these peptides described in the literature are of cyanobacterial origin. Interestingly, all the linear peptides featured with terminal alkyne were solely discovered from marine cyanobacteria. The objective of this article is to provide an overview on the types, structural characterization of these unusual terminal alkynyl fatty acyl units, as well as the sources and biological functions of their composed peptides. Many of these peptides have a variety of biological activities, including antitumor, antibacterial, antimalarial, etc. Further, we have also discussed the evident biosynthetic origin responsible for formation of terminal alkynes of natural PKS (polyketide synthase)/NRPS (nonribosome peptide synthetase) hybrids. MDPI 2016-11-23 /pmc/articles/PMC5128759/ /pubmed/27886049 http://dx.doi.org/10.3390/md14110216 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chai, Qiu-Ye
Yang, Zhen
Lin, Hou-Wen
Han, Bing-Nan
Alkynyl-Containing Peptides of Marine Origin: A Review
title Alkynyl-Containing Peptides of Marine Origin: A Review
title_full Alkynyl-Containing Peptides of Marine Origin: A Review
title_fullStr Alkynyl-Containing Peptides of Marine Origin: A Review
title_full_unstemmed Alkynyl-Containing Peptides of Marine Origin: A Review
title_short Alkynyl-Containing Peptides of Marine Origin: A Review
title_sort alkynyl-containing peptides of marine origin: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128759/
https://www.ncbi.nlm.nih.gov/pubmed/27886049
http://dx.doi.org/10.3390/md14110216
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