Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein

Alpha-synuclein (α-Syn) is a small presynaptic protein of 140 amino acids. Its pathologic intracellular aggregation within the central nervous system yields protein fibrillar inclusions named Lewy bodies that are the hallmarks of Parkinson’s disease (PD). In solution, pure α-Syn adopts an intrinsica...

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Detalles Bibliográficos
Autores principales: Makky, Ali, Bousset, Luc, Polesel-Maris, Jérôme, Melki, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128817/
https://www.ncbi.nlm.nih.gov/pubmed/27901068
http://dx.doi.org/10.1038/srep37970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128817/
https://www.ncbi.nlm.nih.gov/pubmed/27901068
http://dx.doi.org/10.1038/srep37970

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