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Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition

Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433 inhibits several excitatory ligand-gated ion channels, and to improve selectivity two synthetic analogues, PhTX-343 and PhTX-12, were developed. Previous work showed a 22-...

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Detalles Bibliográficos
Autores principales:	Kachel, Hamid S., Patel, Rohit N., Franzyk, Henrik, Mellor, Ian R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128878/ https://www.ncbi.nlm.nih.gov/pubmed/27901080 http://dx.doi.org/10.1038/srep38116

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