p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway

Activation of p53 in response to DNA damage is essential for tumor suppression. Although previous studies have emphasized the importance of p53-dependent cell cycle arrest and apoptosis for tumor suppression, recent studies have suggested that other areas of p53 regulation, such as metabolism and DN...

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Detalles Bibliográficos
Autores principales: Franklin, Derek A., He, Yizhou, Leslie, Patrick L., Tikunov, Andrey P., Fenger, Nick, Macdonald, Jeffrey M., Zhang, Yanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128917/
https://www.ncbi.nlm.nih.gov/pubmed/27901115
http://dx.doi.org/10.1038/srep38067

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