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Alcohol consumption over time and mortality in the Swedish Women’s Lifestyle and Health cohort

BACKGROUND: Alcohol consumption is steadily increasing in high-income countries but the harm and possible net benefits of light-to-moderate drinking remain controversial. We prospectively investigated the association between time-varying alcohol consumption and overall and cause-specific mortality a...

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Autores principales: Licaj, Idlir, Sandin, Sven, Skeie, Guri, Adami, Hans-Olov, Roswall, Nina, Weiderpass, Elisabete
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129127/
https://www.ncbi.nlm.nih.gov/pubmed/27807087
http://dx.doi.org/10.1136/bmjopen-2016-012862
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author Licaj, Idlir
Sandin, Sven
Skeie, Guri
Adami, Hans-Olov
Roswall, Nina
Weiderpass, Elisabete
author_facet Licaj, Idlir
Sandin, Sven
Skeie, Guri
Adami, Hans-Olov
Roswall, Nina
Weiderpass, Elisabete
author_sort Licaj, Idlir
collection PubMed
description BACKGROUND: Alcohol consumption is steadily increasing in high-income countries but the harm and possible net benefits of light-to-moderate drinking remain controversial. We prospectively investigated the association between time-varying alcohol consumption and overall and cause-specific mortality among middle-aged women. METHODS: Among 48 249 women at baseline (33 404 at follow-up) in the prospective Swedish Women's Lifestyle and Health cohort, age 30–49 years at baseline, we used repeated information on alcohol consumption and combined this method with multiple imputation in order to maximise the number of participants and deaths included in the analyses. Multivariable Cox regression models were used to calculate HRs for overall and cause-specific mortality. RESULTS: During >900 000 person/years, a total of 2100 deaths were recorded through Swedish registries. The median alcohol consumption increased from 2.3 g/day in 1991/1992 (baseline) to 4.7 g/day in 2004 (follow-up). Compared with light drinkers (0.1–1.5 g/day), a null association was observed for all categories of alcohol consumption with the exception of never drinkers. The HR comparing never with light drinkers was 1.46 (95% CI 1.22 to 1.74). There was a statistically significant negative trend between increasing alcohol consumption and cardiovascular and ischaemic heart diseases mortality. The results were similar when women with prevalent conditions were excluded. CONCLUSIONS: In conclusion, in a cohort of young women, light alcohol consumption was protective for cardiovascular and ischaemic heart disease mortality but not for cancer and overall mortality.
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spelling pubmed-51291272016-12-08 Alcohol consumption over time and mortality in the Swedish Women’s Lifestyle and Health cohort Licaj, Idlir Sandin, Sven Skeie, Guri Adami, Hans-Olov Roswall, Nina Weiderpass, Elisabete BMJ Open Public Health BACKGROUND: Alcohol consumption is steadily increasing in high-income countries but the harm and possible net benefits of light-to-moderate drinking remain controversial. We prospectively investigated the association between time-varying alcohol consumption and overall and cause-specific mortality among middle-aged women. METHODS: Among 48 249 women at baseline (33 404 at follow-up) in the prospective Swedish Women's Lifestyle and Health cohort, age 30–49 years at baseline, we used repeated information on alcohol consumption and combined this method with multiple imputation in order to maximise the number of participants and deaths included in the analyses. Multivariable Cox regression models were used to calculate HRs for overall and cause-specific mortality. RESULTS: During >900 000 person/years, a total of 2100 deaths were recorded through Swedish registries. The median alcohol consumption increased from 2.3 g/day in 1991/1992 (baseline) to 4.7 g/day in 2004 (follow-up). Compared with light drinkers (0.1–1.5 g/day), a null association was observed for all categories of alcohol consumption with the exception of never drinkers. The HR comparing never with light drinkers was 1.46 (95% CI 1.22 to 1.74). There was a statistically significant negative trend between increasing alcohol consumption and cardiovascular and ischaemic heart diseases mortality. The results were similar when women with prevalent conditions were excluded. CONCLUSIONS: In conclusion, in a cohort of young women, light alcohol consumption was protective for cardiovascular and ischaemic heart disease mortality but not for cancer and overall mortality. BMJ Publishing Group 2016-11-02 /pmc/articles/PMC5129127/ /pubmed/27807087 http://dx.doi.org/10.1136/bmjopen-2016-012862 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Public Health
Licaj, Idlir
Sandin, Sven
Skeie, Guri
Adami, Hans-Olov
Roswall, Nina
Weiderpass, Elisabete
Alcohol consumption over time and mortality in the Swedish Women’s Lifestyle and Health cohort
title Alcohol consumption over time and mortality in the Swedish Women’s Lifestyle and Health cohort
title_full Alcohol consumption over time and mortality in the Swedish Women’s Lifestyle and Health cohort
title_fullStr Alcohol consumption over time and mortality in the Swedish Women’s Lifestyle and Health cohort
title_full_unstemmed Alcohol consumption over time and mortality in the Swedish Women’s Lifestyle and Health cohort
title_short Alcohol consumption over time and mortality in the Swedish Women’s Lifestyle and Health cohort
title_sort alcohol consumption over time and mortality in the swedish women’s lifestyle and health cohort
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129127/
https://www.ncbi.nlm.nih.gov/pubmed/27807087
http://dx.doi.org/10.1136/bmjopen-2016-012862
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