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Associations of Breast Cancer Risk Factors with Premenopausal Sex Hormones in Women with Very Low Breast Cancer Risk

Breast cancer incidence rates are low but rising in urban Mongolia. We collected reproductive and lifestyle factor information and measured anthropometrics and serum sex steroid concentrations among 314 premenopausal women living in Ulaanbaatar, Mongolia. Mean differences in hormone concentrations b...

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Autores principales: Houghton, Lauren C., Ganmaa, Davaasambuu, Rosenberg, Philip S., Davaalkham, Dambadarjaa, Stanczyk, Frank Z., Hoover, Robert N., Troisi, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129276/
https://www.ncbi.nlm.nih.gov/pubmed/27809264
http://dx.doi.org/10.3390/ijerph13111066
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author Houghton, Lauren C.
Ganmaa, Davaasambuu
Rosenberg, Philip S.
Davaalkham, Dambadarjaa
Stanczyk, Frank Z.
Hoover, Robert N.
Troisi, Rebecca
author_facet Houghton, Lauren C.
Ganmaa, Davaasambuu
Rosenberg, Philip S.
Davaalkham, Dambadarjaa
Stanczyk, Frank Z.
Hoover, Robert N.
Troisi, Rebecca
author_sort Houghton, Lauren C.
collection PubMed
description Breast cancer incidence rates are low but rising in urban Mongolia. We collected reproductive and lifestyle factor information and measured anthropometrics and serum sex steroid concentrations among 314 premenopausal women living in Ulaanbaatar, Mongolia. Mean differences in hormone concentrations by these factors were calculated using age-adjusted quadratic regression splines. Estrone and estradiol in college-educated women were, respectively, 18.2% (p = 0.03) and 23.6% (p = 0.03) lower than in high-school-educated women. Progesterone concentrations appeared 55.8% lower (p = 0.10) in women residing in modern housing compared with women living in traditional housing (gers), although this finding was not statistically significant. Testosterone concentrations were positively associated with adiposity and central fat distribution; 17.1% difference (p = 0.001) for highest vs. lowest quarter for body mass index and 15.1% difference (p = 0.005) for waist-to-height ratio. Estrogens were higher in the follicular phase of women who breastfed each child for shorter durations. A distinct hormonal profile was associated with an urban lifestyle in premenopausal, Mongol women. In particular, heavier, more-educated women living in urban dwellings had higher testosterone and lower estrogen and progesterone levels. Higher breast cancer incidence in urban compared with rural women suggest that the hormonal profile associated with a more traditional lifestyle may be protective among Mongol women.
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spelling pubmed-51292762016-12-11 Associations of Breast Cancer Risk Factors with Premenopausal Sex Hormones in Women with Very Low Breast Cancer Risk Houghton, Lauren C. Ganmaa, Davaasambuu Rosenberg, Philip S. Davaalkham, Dambadarjaa Stanczyk, Frank Z. Hoover, Robert N. Troisi, Rebecca Int J Environ Res Public Health Article Breast cancer incidence rates are low but rising in urban Mongolia. We collected reproductive and lifestyle factor information and measured anthropometrics and serum sex steroid concentrations among 314 premenopausal women living in Ulaanbaatar, Mongolia. Mean differences in hormone concentrations by these factors were calculated using age-adjusted quadratic regression splines. Estrone and estradiol in college-educated women were, respectively, 18.2% (p = 0.03) and 23.6% (p = 0.03) lower than in high-school-educated women. Progesterone concentrations appeared 55.8% lower (p = 0.10) in women residing in modern housing compared with women living in traditional housing (gers), although this finding was not statistically significant. Testosterone concentrations were positively associated with adiposity and central fat distribution; 17.1% difference (p = 0.001) for highest vs. lowest quarter for body mass index and 15.1% difference (p = 0.005) for waist-to-height ratio. Estrogens were higher in the follicular phase of women who breastfed each child for shorter durations. A distinct hormonal profile was associated with an urban lifestyle in premenopausal, Mongol women. In particular, heavier, more-educated women living in urban dwellings had higher testosterone and lower estrogen and progesterone levels. Higher breast cancer incidence in urban compared with rural women suggest that the hormonal profile associated with a more traditional lifestyle may be protective among Mongol women. MDPI 2016-10-31 2016-11 /pmc/articles/PMC5129276/ /pubmed/27809264 http://dx.doi.org/10.3390/ijerph13111066 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Houghton, Lauren C.
Ganmaa, Davaasambuu
Rosenberg, Philip S.
Davaalkham, Dambadarjaa
Stanczyk, Frank Z.
Hoover, Robert N.
Troisi, Rebecca
Associations of Breast Cancer Risk Factors with Premenopausal Sex Hormones in Women with Very Low Breast Cancer Risk
title Associations of Breast Cancer Risk Factors with Premenopausal Sex Hormones in Women with Very Low Breast Cancer Risk
title_full Associations of Breast Cancer Risk Factors with Premenopausal Sex Hormones in Women with Very Low Breast Cancer Risk
title_fullStr Associations of Breast Cancer Risk Factors with Premenopausal Sex Hormones in Women with Very Low Breast Cancer Risk
title_full_unstemmed Associations of Breast Cancer Risk Factors with Premenopausal Sex Hormones in Women with Very Low Breast Cancer Risk
title_short Associations of Breast Cancer Risk Factors with Premenopausal Sex Hormones in Women with Very Low Breast Cancer Risk
title_sort associations of breast cancer risk factors with premenopausal sex hormones in women with very low breast cancer risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129276/
https://www.ncbi.nlm.nih.gov/pubmed/27809264
http://dx.doi.org/10.3390/ijerph13111066
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