Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells

Cells in homeostasis metabolize glucose mainly through the tricarboxylic acid cycle and oxidative phosphorylation, while activated cells switch their basal metabolism to aerobic glycolysis. In this study, we examined whether metabolic reprogramming toward aerobic glycolysis is important for the host...

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Detalles Bibliográficos
Autores principales: Lachmandas, Ekta, Beigier‐Bompadre, Macarena, Cheng, Shih‐Chin, Kumar, Vinod, van Laarhoven, Arjan, Wang, Xinhui, Ammerdorffer, Anne, Boutens, Lily, de Jong, Dirk, Kanneganti, Thirumala‐Devi, Gresnigt, Mark S., Ottenhoff, Tom H.M., Joosten, Leo A.B., Stienstra, Rinke, Wijmenga, Cisca, Kaufmann, Stefan H.E., van Crevel, Reinout, Netea, Mihai G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Immunity to infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129526/
https://www.ncbi.nlm.nih.gov/pubmed/27624090
http://dx.doi.org/10.1002/eji.201546259

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