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Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1

Aims-SIRT1 exerts potent activity against cellular senescence and vascular ageing. By decreasing LKB1 protein levels, it promotes the survival and regeneration of endothelial cells. The present study aims to investigate the molecular mechanisms underlying SIRT1-mediated LKB1 degradation for the prev...

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Detalles Bibliográficos
Autores principales:	Bai, Bo, Man, Andy W.C., Yang, Kangmin, Guo, Yumeng, Xu, Cheng, Tse, Hung-Fat, Han, Weiping, Bloksgaard, Maria, De Mey, Jo G.R., Vanhoutte, Paul M., Xu, Aimin, Wang, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129914/ https://www.ncbi.nlm.nih.gov/pubmed/27259994 http://dx.doi.org/10.18632/oncotarget.9687

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