Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQ(Q209P)-driven uveal melanomas in zebrafish

Mutations affecting Gαq proteins are pervasive in uveal melanoma (UM), suggesting they ‘drive’ UM pathogenesis. The ERK1/2-MAPK pathway is critical for cutaneous melanoma development and consequently an important therapeutic target. Defining the contribution of ERK1/2-MAPK signalling to UM developme...

Descripción completa

Detalles Bibliográficos
Autores principales: Mouti, Mai Abdel, Dee, Christopher, Coupland, Sarah E., Hurlstone, Adam F.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129960/
https://www.ncbi.nlm.nih.gov/pubmed/27166257
http://dx.doi.org/10.18632/oncotarget.9207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129960/
https://www.ncbi.nlm.nih.gov/pubmed/27166257
http://dx.doi.org/10.18632/oncotarget.9207

Ejemplares similares